Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist (ab142085)
Key features and details
- TLR1/TLR2 agonist
- CAS Number: 112208-00-1
- Purity: > 95%
- Soluble in 1:1 water/ethanol to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist -
製品の詳細
TLR1/TLR2 agonist -
別名
- pam3CSK4
-
生理活性の詳細
TLR1/TLR2 agonist. Synthetic analog of the triacylated N-terminal part of bacterial lipoproteins. Potent adjuvant in vivo. Potent activator of Balb/c splenocytes.
-
精製度
> 95% -
CAS 番号
112208-00-1 -
構造式
製品の特性
-
分子量
1510.24 -
分子式
C81H156N10O13S -
配列
CSKKKK (Modifications: N-terminal palmitoyl; Cys-1 = Cys(2,3-Bis(palmitoyloxy)propyl)) -
PubChem 登録番号
130704 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 1:1 water/ethanol to 1 mg/ml -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O -
由来
Synthetic
-
研究分野
画像
-
Chemical Structure - Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist (ab142085)2D chemical structure image of ab142085, Pam3Cys-Ser-(Lys)4, TLR1/TLR2 agonist
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (11)
ab142085 は 11 報の論文で使用されています。
- Liu X et al. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO Mol Med 15:e15631 (2023). PubMed: 36453131
- Mansouri A et al. Sperm activate TLR2/TLR1 heterodimerization to induce a weak proinflammatory response in the bovine uterus. Front Immunol 14:1158090 (2023). PubMed: 37180107
- Jiang S et al. Bacterial lipoprotein plays an important role in the macrophage autophagy and apoptosis induced by Salmonella typhimurium and Staphylococcus aureus. Open Life Sci 18:20220739 (2023). PubMed: 37791056
- Akthar I et al. Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle. Front Immunol 14:1319572 (2023). PubMed: 38179051
- Ma D et al. Toll-like Receptor 2 is Involved in Calcium Influx and Acrosome Reaction to Facilitate Sperm Penetration to Oocytes During in vitro Fertilization in Cattle. Front Cell Dev Biol 10:810961 (2022). PubMed: 35281105
