AB120736

Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist

Name: Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (ab120736)
Brand: Abcam Limited
SKU: AB120736
Price: 10000 JPY
Availability: InStock

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MW 312.43 g/mol, Purity >99%. 5-HT and D₂ antagonist (K_i values are 4 (5-HT_2A), 11 (5-HT_2C) and 57 (5-HT₃), 31 (D₁), 11 (D₂) and 27 nM (D₄)). Additionally, displays activity at: M₁, M₂, M₃, M₄, H₁, α₁ and α₂ receptors (K_i are 1.9 at (M₁), 18 (M₂), 25 (M₃), 13 (M₄), 19 (α₁) and 7 nM (α₂)). Atypical antipsychotic. Displays anxiolytic activity.

2 Images

Immunocytochemistry/ Immunofluorescence - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)

ab32572 staining β catenin in SKNSH cells treated with olanzapine (ab120736), by ICC/IF. Increase in expression of β catenin correlates with increased concentration of olanzapine, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120736 (olanzapine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32572 (1/200 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight^® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)

Chemical Structure

Lab

Chemical Structure - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (AB120736)

2D chemical structure image of ab120736, Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist

Key facts

CAS番号

132539-06-1

精製度

>99%

製品の状態

Solid

form

分子量

312.43 g/mol

分子式

C17H20N4S

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

生物学的記述

5-HT and D₂ antagonist (K_i values are 4 (5-HT_2A), 11 (5-HT_2C) and 57 (5-HT₃), 31 (D₁), 11 (D₂) and 27 nM (D₄)). Additionally, displays activity at: M₁, M₂, M₃, M₄, H₁, α₁ and α₂ receptors (K_i are 1.9 at (M₁), 18 (M₂), 25 (M₃), 13 (M₄), 19 (α₁) and 7 nM (α₂)). Atypical antipsychotic. Displays anxiolytic activity.

IUPAC名

2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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製品プロトコール

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Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist