NVS-PAK1-1, PAK1 inhibitor (ab146939)
Key features and details
- Potent allosteric inhibitor of PAK1
- CAS Number: 1783816-74-9
- Purity: > 98%
Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Lyophilized
- Source: Synthetic
製品の概要
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製品名
NVS-PAK1-1, PAK1 inhibitor -
製品の詳細
Potent allosteric inhibitor of PAK1 -
生理活性の詳細
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1. It has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro assay. It is more than 50-fold more active against PAK1 than against PAK2. NVS-PAK1-1 is highly selective in a panel of 442 kinases. NVS-PAK1-1 potently inhibits PAK1 autophosphorylation in cell-based assays.
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精製度
> 98% -
CAS 番号
1783816-74-9 -
構造式
製品の特性
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体系名
(S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
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分子量
479.93 -
分子式
C23H25ClF3N5O -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in ethanol to 100 mM and in DMSO to 100 mM
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使用に関する注意
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
O=C(NC(C)C)N4CC[C@H](NC1=Nc3cc(F)ccc3N(CC(F)F)c2ccc(Cl)cc12)C4 -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab146939 は 1 報の論文で使用されています。
- Karpov AS et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett 6:776-81 (2015). PubMed: 26191365
