Nicotinamide, PARP inhibitor (ab120864)
Key features and details
- Amide form of vitamin B3
- CAS Number: 98-92-0
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Nicotinamide, PARP inhibitor -
製品の詳細
Amide form of vitamin B3 -
生理活性の詳細
Amide form of vitamin B3. Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD+). Essential for the synthesis of NAD+ phosphate (NADP+). Essential for energy metabolism, normal physiology and disease progression. Associated with a number of signaling pathways including oxidative stress, cell survival and inflammation. These effects are orchestrated partly through forkhead, Akt, Bad, caspase, MAPK and PARP signaling. Non-selective sirtuin inhibitor. Commonly used as 3D growth matrix components and additive for long-term growth.
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精製度
> 99% -
CAS 番号
98-92-0 -
構造式
製品の特性
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体系名
Pyridine-3-carboxamide -
分子量
122.13 -
分子式
C6H6N2O -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120864 は 4 報の論文で使用されています。
- Huang X et al. Ginsenoside Rk2 Protects against Ulcerative Colitis via Inactivating ERK/MEK Pathway by SIRT1. J Environ Pathol Toxicol Oncol 41:89-98 (2022). PubMed: 35695654
- Adamkova K et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol 8:83 (2017). PubMed: 29118980
- Zou D et al. Correction: Protective Effects of Myricetin on Acute Hypoxia-Induced Exercise Intolerance and Mitochondrial Impairments in Rats. PLoS One 10:e0133336 (2015). PubMed: 26176666
- Zou D et al. Protective effects of myricetin on acute hypoxia-induced exercise intolerance and mitochondrial impairments in rats. PLoS One 10:e0124727 (2015). PubMed: 25919288