N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)
Key features and details
- Potent endogenous chemotactic peptide
- CAS Number: 59880-97-6
- Purity: > 98%
- Soluble in ethanol to 5 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide -
製品の詳細
Potent endogenous chemotactic peptide -
生理活性の詳細
Potent endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Chemoattractant for phagocytic leukocytes. Stimulates random and directed locomotion. Inducer of superoxide release. Active in vitro.
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精製度
> 98% -
CAS 番号
59880-97-6 -
構造式
製品の特性
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分子量
437.55 -
分子式
C21H31N3O5S -
配列
MLF (Modifications: N-terminal formyl) -
PubChem 登録番号
443295 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 5 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O -
由来
Synthetic
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研究分野
画像
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Chemical Structure - N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)2D chemical structure image of ab141806, N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide
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Functional Studies - N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)N-Formyl-Met-Leu-Phe activates Ca2+ transients in differentiated HL-60 cells.Cells were loaded with Fluo-3 AM (ab145254). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application (indicated by arrow) of 1 µM N-Formyl-Met-Leu-Phe (ab141806), (green) compared to control (black, saline perfusion).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab141806 は 1 報の論文で使用されています。
- Cuesta Torres LF et al. High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer. Atherosclerosis 286:20-29 (2019). PubMed: 31096070
