MSOP, group III metabotropic glutamate receptor antagonist (ab141381)

Potent, selective group III metabotropic glutamate receptor antagonist. Selective inhibition for L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord (K_D = 51 μM) compared to the (1S,3S)-ACPD-sensitive presynaptic mGlu (K_D > 700 μM). No activity on postsynaptic mGlu receptors or ionotropic glutamate receptors on neonatal rat motoneurons.


Also available in simple stock solutions (ab146735) - add 1 ml of water to get an exact, ready-to-use concentration.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

 Toxic, refer to SDS for further information

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Synthetic

• Neuroscience
• Neurotransmitter
• Amino Acids
• Glutamate

• Neuroscience
• Neurotransmission
• Receptors / Channels
• GPCR
• Glutamate Receptors

• Signal Transduction
• Signaling Pathway
• G Protein Signaling
• GPCR

• Biochemicals
• Chemical Type
• Biochemicals

• Biochemicals
• Chemical Type
• Antibiotic

• Biochemicals
• Pharmacology
• Receptors & Transporters
• Glutamate
• mGlu
• Group III
• Antagonists

• Neuroscience
• Processes