ML 204, TRPC4 blocker

Key facts

CAS番号

5465-86-1

製品の状態

Solid

form

分子量

226.32 Da

分子式

C₁₅H₁₈N₂

PubChem

230710

由来

Synthetic

溶解性

Soluble in DMSO to 75 mM

化学名

4-Methyl-2-(piperidin-1-yl)quinoline

生物学的記述

Selective TRPC4 channel blocker (IC₅₀ = 0.96 (fluorescence assay) - 2.6 μM (electrophysiological assay)). Selective versus TRPC6 (19-fold) and TRPC5 (9-fold). Essentially inactive at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Canonical smiles

CC1=CC(=NC2=CC=CC=C12)N3CCCCC3

InChi

InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3

InChiKey

USYRQXDHKXGTCK-UHFFFAOYSA-N

IUPAC名

4-methyl-2-piperidin-1-ylquinoline