MK886, Lipoxygenase inhibitor (ab141140)
Key features and details
- Potent lipoxygenase inhibitor
- CAS Number: 118414-82-7
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
MK886, Lipoxygenase inhibitor -
製品の詳細
Potent lipoxygenase inhibitor -
生理活性の詳細
Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC50 = 44 nM). Inhibits leukotriene biosynthesis (IC50 = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
-
精製度
> 98% -
CAS 番号
118414-82-7 -
構造式
製品の特性
-
体系名
1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid -
分子量
472.08 -
分子式
C27H34ClNO2S -
PubChem 登録番号
4519262 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
O=C(O)C(C)(C)Cc3c(SC(C)(C)C)c1cc(ccc1n3Cc2ccc(Cl)cc2)C(C)C -
由来
Synthetic
-
研究分野
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
関連製品
-
Related Products
画像
-
Chemical Structure - MK886, Lipoxygenase inhibitor (ab141140)2D chemical structure image of ab141140, MK886, Lipoxygenase inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab141140 は 2 報の論文で使用されています。
- Huang Y et al. Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARa pathway. Appl Physiol Nutr Metab 45:227-239 (2020). PubMed: 31173696
- Tao T et al. Role of adiponectin/peroxisome proliferator-activated receptor alpha signaling in human chorionic gonadotropin-induced estradiol synthesis in human luteinized granulosa cells. Mol Cell Endocrinol 493:110450 (2019). PubMed: 31116958
