MK-1775 (ab147242)
Key features and details
- Potent and selective small-molecule inhibitor of Wee1 kinase
- CAS Number: 955365-80-7
- Purity: > 98%
Soluble in DMSO to 200 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
MK-1775 -
製品の詳細
Potent and selective small-molecule inhibitor of Wee1 kinase -
別名
- AZD 1775
- MK1775
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生理活性の詳細
Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC50 = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays. Acts synergistically with gemcitabine in tumor cells. In a panel of 223 kinases, only 8 were inhibited >80% by 1μM MK-1775.
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精製度
> 98% -
CAS 番号
955365-80-7 -
構造式
製品の特性
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体系名
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo [3,4-d]pyrimidin-3-one
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分子量
500.60 -
分子式
C27H32N8O2 -
PubChem 登録番号
24856436 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in DMSO to 200 mM
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使用に関する注意
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O -
由来
Synthetic
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研究分野
画像
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Chemical Structure - MK-1775 (ab147242)
Chemical structure of MK-1775, 955365-80-7
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab147242 は論文での使用が確認できていません。