Methoxy-X04, amyloid beta fluorescent marker (ab142818)
Key features and details
- Blood-brain barrier permeable amyloid β fluorescent marker
- CAS Number: 863918-78-9
- Purity: > 98%
Soluble in DMSO to 100 mM and in ethanol to 20 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Methoxy-X04, amyloid beta fluorescent marker -
製品の詳細
Blood-brain barrier permeable amyloid β fluorescent marker -
生理活性の詳細
Blood-brain barrier permeable amyloid β fluorescent marker. Blue fluorophore. Derivative of Congo Red (ab145645) and Chrysamine G. Selectively binds fibrillar β-sheet deposits with high affinity (Ki = 26.8 nM). Detects plaques, tangles and cerebrovascular amyloid in vivo.
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精製度
> 98% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 2664 Methoxy-X04. 2664-25 is the same size as the 25 mg size of ab142818.
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CAS 番号
863918-78-9 -
構造式
製品の特性
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体系名
2,5-Bis(2-(4-hydroxyphenyl)vinyl)anisole
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分子量
344.41 -
分子式
C23H20O3 -
PubChem 登録番号
16049314 -
保存方法
Store at +4°C. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 20 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
COc2cc(cc(/C=C/c1ccc(O)cc1)c2)/C=C/c3ccc(O)cc3 -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Methoxy-X04, amyloid beta fluorescent marker (ab142818)2D chemical structure image of ab142818, Methoxy-X04, amyloid beta fluorescent marker
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (5)
ab142818 は 5 報の論文で使用されています。
- Wellman SM et al. Aberrant accumulation of age- and disease-associated factors following neural probe implantation in a mouse model of Alzheimer's disease. J Neural Eng 20:N/A (2023). PubMed: 37531953
- Lonnemann N et al. IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer's disease mouse model. Elife 11:N/A (2022). PubMed: 36040311
- Rudan Njavro J et al. Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model. Cells 12:N/A (2022). PubMed: 36611872
- Honarpisheh P et al. Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-ß in Tg2576 Mice. Int J Mol Sci 21:N/A (2020). PubMed: 32138161
- Klunk WE et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol 61:797-805 (2002). PubMed: 12230326
