MDL 72222, 5-HT3 receptor antagonist (ab146635)
Key features and details
- Selective 5-HT3 receptor antagonist
- CAS Number: 40796-97-2
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
-
製品名
MDL 72222, 5-HT3 receptor antagonist -
製品の詳細
Selective 5-HT3 receptor antagonist -
別名
- 1 alpha H, 3 alpha, 5 alpha H-tropan-3-yl-3,5-dichlorobenzoate
- 3-Tropanyl-3,5-dichlorobenzoate
- Bemesetron
see all -
生理活性の詳細
Selective 5-HT3 receptor antagonist. Shows antiemetic effects in vivo. Suppresses voluntary ethanol consumption that is mediated by 5-HT3 receptor in rats.
-
精製度
> 99% -
CAS 番号
40796-97-2 -
構造式
製品の特性
-
体系名
3,5-Dichlorobenzoic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester -
分子量
314.21 -
分子式
C15H17Cl2NO2 -
保存方法
Store at room temperature. -
溶解性
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES 線形表記
CN3[C@@H]1CC[C@H]3C[C@H](C1)OC(=O)c2cc(Cl)cc(Cl)c2 -
由来
Synthetic
画像
-
Chemical Structure - MDL 72222, 5-HT3 receptor antagonist (ab146635)2D chemical structure image of ab146635, MDL 72222, 5-HT3 receptor antagonist
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab146635 は 4 報の論文で使用されています。
- Kos T et al. Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice. Eur Neuropsychopharmacol 16:297-310 (2006). PubMed: 16288851
- Homesley HD et al. Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen. Am J Clin Oncol 16:175-9 (1993). PubMed: 8452114
- Fadda F et al. MDL 72222, a selective 5-HT3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats. Alcohol Alcohol 26:107-10 (1991). PubMed: 1878073
- Fozard JR MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch Pharmacol 326:36-44 (1984). PubMed: 6472484