MCAAD-3, Near-infrared probe for imaging of amyloid plaques

Key facts

CAS番号

1625629-51-7

精製度

>99%

製品の状態

Solid

form

分子量

282.34 g/mol

分子式

C₁₇H₁₈N₂O₂

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

生物学的記述

Near-infrared probe for imaging of amyloid plaques in Alzheimer's disease. DANIR 2c analog that shows extended emission wavelength and significant reduced binding affinity to Aβ aggregates compared with DANIR 2c. In vivo imaging studies suggest that MCAAD-3 can penetrate the blood–brain barrier and label Aβ plaques in the brains of transgenic mice.

Isomeric smiles

CN(C)C1CCC(/C=C/C=C/C=C(/C#N)C(=O)OC)CC1

InChi

InChI=1S/C17H18N2O2/c1-19(2)16-11-9-14(10-12-16)7-5-4-6-8-15(13-18)17(20)21-3/h4-12H,1-3H3/b6-4+,7-5+,15-8-

IUPAC名

methyl (2Z,4E,6E)-2-cyano-7-[4-(dimethylamino)]hepta-2,4,6-trienoate