AB120196

LY 379268, Group II mGlu agonist

Name: LY 379268, Group II mGlu agonist (ab120196) | Abcam
Brand: Abcam Limited
SKU: AB120196
Price: 69000 JPY
Availability: InStock

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(8 Publications)

MW 187.15 Da, Purity >99%. Highly potent and systemically active mGlu₂ and mGlu₃ agonist. EC₅₀ values are 2.69 and 4.48 nM for hmGlu₂ and hmGlu₃, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.

別名を表示する

AMPA-selective glutamate receptor 2, GLUR, GPRC1B, GPRC1C, GRM2_HUMAN, GRM3_HUMAN, GluR-2, GluR-3, GluR-B, Glutamate metabotropic receptor 2, Glutamate metabotropic receptor 3, Glutamate receptor homolog, Glutamate receptor metabotropic 2, Glutamate receptor metabotropic 3, MGLUR2, MGLUR3, MGlu3, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, OTTHUMP00000210984, OTTHUMP00000210986, Smp_128940, mGlu2

1 Images

Chemical Structure - LY 379268, Group II mGlu agonist (AB120196)

Chemical Structure

Lab

Chemical Structure - LY 379268, Group II mGlu agonist (AB120196)

2D chemical structure image of ab120196, LY 379268, Group II mGlu agonist

Key facts

CAS番号

191471-52-0

精製度

>99%

製品の状態

Solid

form

分子量

187.15 Da

分子式

C7H9NO5

PubChem

10197984

由来

Synthetic

溶解性

Soluble in water to 25 mM (with heating)

化学名

(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

生物学的記述

Highly potent and systemically active mGlu₂ and mGlu₃ agonist. EC₅₀ values are 2.69 and 4.48 nM for hmGlu₂ and hmGlu₃, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.

Canonical smiles

C1C(C2C(C2O1)C(=O)O)(C(=O)O)N

Isomeric smiles

C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N

InChi

InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1

InChiKey

YASVRZWVUGJELU-MDASVERJSA-N

IUPAC名

(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Biology of reproduction 107:916-927 PubMed35746896

2022

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

Applications

Unspecified application

Species

Unspecified reactive species

Alexandra Špirková,Veronika Kovaříková,Zuzana Šefčíková,Jozef Pisko,Martina Kšiňanová,Juraj Koppel,Dušan Fabian,Štefan Čikoš

Neural regeneration research 16:727-733 PubMed33063735

2020

Abnormal Glu/mGluR/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Liu,Yuan-Shan Han,Lin Liu,Lin Tang,Hui Yang,Pan Meng,Hong-Qing Zhao,Yu-Hong Wang

Frontiers in cellular neuroscience 9:345 PubMed26388733

2015

Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.

Applications

Unspecified application

Species

Unspecified reactive species

Luca Bragina,Tiziana Bonifacino,Silvia Bassi,Marco Milanese,Giambattista Bonanno,Fiorenzo Conti

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:79-94 PubMed24381270

2014

Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.

Applications

Unspecified application

Species

Unspecified reactive species

Shen Yin,Meredith J Noetzel,Kari A Johnson,Rocio Zamorano,Nidhi Jalan-Sakrikar,Karen J Gregory,P Jeffrey Conn,Colleen M Niswender

Behavioural brain research 253:9-16 PubMed23827202

2013

Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning.

Applications

Unspecified application

Species

Unspecified reactive species

D Klakotskaia,A K Ramsey,S W Fowler,P Serfozo,A Simonyi,T R Schachtman

Neuropsychopharmacology : official publication of 38:2220-30 PubMed23670591

2013

Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine.

Applications

Unspecified application

Species

Unspecified reactive species

Bruna Cuccurazzu,Valeria Bortolotto,Maria Maddalena Valente,Federica Ubezio,Aleardo Koverech,Pier Luigi Canonico,Mariagrazia Grilli

Neuropsychopharmacology : official publication of 36:1599-607 PubMed21451497

2011

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Heather B Gosnell,Yuval Silberman,Brad A Grueter,Robert M Duvoisin,Jacob Raber,Danny G Winder

The Journal of pharmacology and experimental thera 330:227-35 PubMed19357321

2009

Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Daniella Rylander,Alessandra Recchia,Flora Mela,Andrzej Dekundy,Wojciech Danysz,M Angela Cenci

View all publications

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LY 379268, Group II mGlu agonist