LY 2228820, p38 MAPK inhibitor (ab143833)
Key features and details
- A novel and potent inhibitor of p38 MAPK
- CAS Number: 862507-23-1
- Purity: > 98%
Soluble in water to 163.2 mM, in DMSO to 6.52 mM and in Ethanol to 4.89 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
LY 2228820, p38 MAPK inhibitor -
製品の詳細
A novel and potent inhibitor of p38 MAPK -
別名
- 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid
- LY2228820 dimesylate
- Mesylate
see all -
生理活性の詳細
LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC50 of 7 nM in a cell-free assay.
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精製度
> 98% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called B1702 LY2228820. B1702-25 is the same size as the 25 mg size of ab143833.
Protect from air and light.
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CAS 番号
862507-23-1 -
構造式
製品の特性
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体系名
5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate
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分子量
612.74 -
分子式
C26H37FN6O6S2 -
PubChem 登録番号
11570805 -
保存方法
Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions. -
溶解性
Soluble in water to 163.2 mM, in DMSO to 6.52 mM and in Ethanol to 4.89 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O -
由来
Synthetic
画像
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Chemical Structure - LY 2228820, p38 MAPK inhibitor (ab143833)2D chemical structure image of ab143833, LY 2228820, p38 MAPK inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (0)
ab143833 は論文での使用が確認できていません。
