LFM-A13, BTK inhibitor

Key facts

CAS番号

62004-35-7

精製度

>97%

製品の状態

Solid

form

分子量

360 Da

分子式

C₁₁H₈Br₂N₂O₂

PubChem

54686938

由来

Synthetic

溶解性

Soluble in DMSO to 25 mM

化学名

2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

生物学的記述

Selective Bruton's tyrosine kinase (BTK) inhibitor (IC₅₀ = 2.5 μM). Also inhibits polio-like kinase (Plk1) (IC₅₀ = 37.36 μM). Does not effect EGF receptor, insulin recptor, JAK-1 JAK-2, JAK-3, SYK or HCK (IC₅₀ values are all >300 μM). Anticancer and antileukemic agent. Active in vivo.

Canonical smiles

CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O

InChi

InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)

InChiKey

UVSVTDVJQAJIFG-UHFFFAOYSA-N

IUPAC名

2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide