AB141487

LDN-57444, UCH-L1 inhibitor

Name: LDN-57444, UCH-L1 inhibitor (ab141487) | Abcam
Brand: Abcam Limited
SKU: AB141487
Price: 21000 JPY
Availability: InStock

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MW 397.6 Da, Purity >98%. Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (K_i = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

1 Images

Chemical Structure - LDN-57444, UCH-L1 inhibitor (AB141487)

Chemical Structure

Lab

Chemical Structure - LDN-57444, UCH-L1 inhibitor (AB141487)

2D chemical structure image of ab141487, LDN-57444, UCH-L1 inhibitor

Key facts

CAS番号

668467-91-2

精製度

>98%

製品の状態

Solid

form

分子量

397.6 Da

分子式

C17H11Cl3N2O3

PubChem

16760696

由来

Synthetic

溶解性

Soluble in DMSO to 50 mM

化学名

(Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

生物学的記述

Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (K_i = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.

Canonical smiles

CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

Isomeric smiles

CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl

InChi

InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

InChiKey

OPQRFPHLZZPCCH-PGMHBOJBSA-N

IUPAC名

[(Z)-[5-chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate

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製品の詳細

This product is manufactured by BioVision, an Abcam company and was previously called 2016 LDN-57444. 2016-25 is the same size as the 25 mg size of ab141487.

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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LDN-57444, UCH-L1 inhibitor