AB141410

Imiquimod, Toll-like receptor 7 agonist

Name: Imiquimod, Toll-like receptor 7 agonist (ab141410) | Abcam
Brand: Abcam Limited
SKU: AB141410
Price: 26000 JPY
Availability: InStock

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MW 240.3 Da, Purity >95%. Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.

別名を表示する

ACLS, ADA1D_HUMAN, ADRA1A, ADRA1L1, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, DNA binding protein, DNA replication inhibitor, GCPS, GEMI_HUMAN, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, GMNN, Gastric receptor 1, Gastric receptor I, Geminin, Geminin DNA replication inhibitor, Glioma associated oncogene family zinc finger 3, HGNC:5183, HH2R, HRH2_HUMAN, Histamine H2 receptor, Histamine receptor H2, OTTHUMP00000039393, OTTHUMP00000161242, OTTHUMP00000161243, Oncogene GLI3, PAP A, PAPB, PPD IV, RP3 369A17.3, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Zinc finger protein GLI 3

1 Images

Chemical Structure - Imiquimod, Toll-like receptor 7 agonist (AB141410)

Chemical Structure

Lab

Chemical Structure - Imiquimod, Toll-like receptor 7 agonist (AB141410)

2D chemical structure image of ab141410, Imiquimod, Toll-like receptor 7 agonist

Key facts

CAS番号

99011-02-6

精製度

>95%

製品の状態

Solid

form

分子量

240.3 Da

分子式

C14H16N4

PubChem

57469

由来

Synthetic

溶解性

Soluble in DMSO to 10 mM (with heating)

化学名

Imiquimod

生物学的記述

Toll-like receptor 7 agonist. Activates NF-κB and stimulates pro-inflammtory cytokines. Immunomodulator, antiviral and antitumor agent. Active in vivo and in vitro.

Canonical smiles

CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N

InChi

InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)

InChiKey

DOUYETYNHWVLEO-UHFFFAOYSA-N

IUPAC名

1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine

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製品の詳細

This product is manufactured by BioVision, an Abcam company and was previously called 1698 Imiquimod. 1698-500 is the same size as the 500 mg size of ab141410.

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Alpha 1 Adrenergic Receptor commonly referred to as ADRA1 is a G-protein coupled receptor with an approximate mass of 60 kDa. It mainly resides in smooth muscle cells throughout the vascular system and also in tissues such as the heart and skin. ADRA1 activates through the binding of catecholamines like norepinephrine leading to subsequent cellular responses. This receptor exhibits at least three different subtypes: ADRA1A ADRA1B and ADRA1D each with distinct roles and expression patterns.

Biological function summary

Alpha 1 Adrenergic Receptor contributes to a wide array of physiological activities including smooth muscle contraction vasoconstriction and pupil dilation. The receptor does not function in isolation but integrates into signaling complexes that modulate intracellular second messenger systems. As a receptor engaged in various critical physiological functions its expression and activity need precise regulation to ensure homeostasis and effective organismal responses.

Pathways

Alpha 1 Adrenergic Receptor is deeply entwined in the adrenergic signaling pathway which significantly impacts the cardiovascular and nervous systems. This receptor activates the phospholipase C pathway resulting in the production of inositol triphosphate (IP3) and diacylglycerol (DAG) which ultimately open calcium channels in the endoplasmic reticulum. Through these pathways ADRA1 interacts with other proteins such as ADRA2 and beta-adrenergic receptors contributing to a balanced sympathetic nervous response.

Alpha 1 Adrenergic Receptor plays a role in conditions like hypertension and benign prostatic hyperplasia (BPH). The receptor's involvement in these diseases often relates to its function in vascular and smooth muscle regulation. Overactivation of ADRA1 may contribute to vasoconstriction leading to hypertension while in BPH it can promote muscle contraction around the prostate. Related proteins such as ADRA2 and phospholipase C have also shown implications in these disorders through similar or complementary pathways.

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製品プロトコール

Visit the General protocols
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Imiquimod, Toll-like receptor 7 agonist