IMD 0354, IKKbeta inhibitor (ab144823)
Key features and details
- Potent, selective cell-permeable IKKβ inhibitor
- CAS Number: 978-62-1
- Purity: > 98%
Soluble in ethanol to 7.74 mM and in DMSO to 262.73 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
IMD 0354, IKKbeta inhibitor -
製品の詳細
Potent, selective cell-permeable IKKβ inhibitor -
生理活性の詳細
Potent, selective cell-permeable IKKβ inhibitor (IC50 = 250 nM). Blocks IκBα phosphorylation and prevents NF-κB p65 nuclear translocation. Reduces IL-1β and MCP-1 production. Shows antiproliferative effects. Shows anti-inflammatory effects in vivo. -
精製度
> 98% -
CAS 番号
978-62-1 -
構造式
製品の特性
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体系名
N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
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分子量
383.67 -
PubChem 登録番号
5081913 -
保存方法
Store at -20°C (desiccating conditions). -
溶解性
Soluble in ethanol to 7.74 mM and in DMSO to 262.73 mM
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使用に関する注意
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Oc2ccc(Cl)cc2C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab144823 は 4 報の論文で使用されています。
- Cuaycal AE et al. Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature. Gut Microbes 15:2252447 (2023). PubMed: 37675983
- Feng X et al. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling. Elife 12:N/A (2023). PubMed: 36912771
- Sheng J et al. Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy. Hepatology 74:1971-1993 (2021). PubMed: 33931882
- Miyagawa Y et al. Evaluation of cancer-derived myocardial impairments using a mouse model. Oncotarget 11:3712-3722 (2020). PubMed: 33110478