AB216471

IKK-16, IkappaB kinase inhibitor

Name: IKK-16, IkappaB kinase inhibitor (ab216471) | Abcam
Brand: Abcam Limited
SKU: AB216471
Price: 43000 JPY
Availability: InStock

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(3 Publications)

MW 520.1 Da. Potent, selective IκB kinase (IKK) inhibitor (IC₅₀ values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

2 Images

Functional Studies - IKK-16, IkappaB kinase inhibitor (AB216471)

FuncS

PubMed

Functional Studies - IKK-16, IkappaB kinase inhibitor (AB216471)

Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.

A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments).

Carretta et al PLoS One. 2017 Dec 14;12(12):e0189102. doi: 10.1371/journal.pone.0189102. eCollection 2017. Fig 5. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

Chemical Structure - IKK-16, IkappaB kinase inhibitor (AB216471)

Chemical Structure

Lab

Chemical Structure - IKK-16, IkappaB kinase inhibitor (AB216471)

2D chemical structure image of ab216471, IKK-16, IkappaB kinase inhibitor

Key facts

CAS番号

1186195-62-9

製品の状態

Solid

form

分子量

520.1 Da

分子式

C28H30ClN5OS

PubChem

56972179

由来

Synthetic

化学名

IKK 16 (hydrochloride)

生物学的記述

Potent, selective IκB kinase (IKK) inhibitor (IC₅₀ values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM. Inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis.

Canonical smiles

C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl

InChi

InChI=1S/C28H29N5OS.ClH/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26;/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31);1H

InChiKey

XFVDIVQCZWDBCW-UHFFFAOYSA-N

IUPAC名

[4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone;hydrochloride

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製品の詳細

This product is manufactured by BioVision, an Abcam company and was previously called B1087 IKK16. B1087-25 is the same size as the 25 mg size of ab216471.

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Store under desiccating conditions

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製品プロトコール

Visit the General protocols
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 29:1211-1227 PubMed34862482

2021

The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.

Applications

Unspecified application

Species

Unspecified reactive species

Evelina Valionyte,Yi Yang,Sophie A Griffiths,Amelia T Bone,Elizabeth R Barrow,Vikram Sharma,Boxun Lu,Shouqing Luo

Glia 69:1478-1493 PubMed33556209

2021

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Fe Lanfranco,Jordy Sepulveda,Gregory Kopetsky,G William Rebeck

PloS one 12:e0189102 PubMed29240787

2017

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Carretta,Annet Z Brouwers-Vos,Matthieu Bosman,Sarah J Horton,Joost H A Martens,Edo Vellenga,Jan Jacob Schuringa

View all publications

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Abcam product promise

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IKK-16, IkappaB kinase inhibitor