Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor

Key facts

CAS番号

120943-99-9

精製度

>98%

製品の状態

Solid

form

分子量

238.18 Da

分子式

C₁₁H₁₁O₄P

PubChem

129317

由来

Synthetic

溶解性

Soluble in ethanol to 100 mM

Soluble in DMSO to 100 mM

化学名

(Hydroxy-2-naphthalenylmethyl)phosphonic acid

生物学的記述

Insulin receptor tyrosine kinase inhibitor (IC₅₀ = 100 μM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Membrane impermeable (membrane permeable analog available ab141567).

Canonical smiles

C1=CC=C2C=C(C=CC2=C1)C(O)P(=O)(O)O

InChi

InChI=1S/C11H11O4P/c12-11(16(13,14)15)10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11-12H,(H2,13,14,15)

InChiKey

AMJJLDJPDLKNJA-UHFFFAOYSA-N

IUPAC名

[hydroxy(naphthalen-2-yl)methyl]phosphonic acid