HBDDE, PKCalpha and PKCgamma inhibitor
HBDDE, PKCalpha and PKCgamma inhibitor
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(2 Publications)
MW 338.31 Da, Purity >97%. PKCα and PKCγ inhibitor (IC50 values are 43 and 50 μM respectively). δ, βI and βII isotypes are not affected. Inducer of apoptosis. Active in vivo.
別名を表示する
AML 1, AML1 EVI 1, AML1 EVI 1 fusion protein, AMLCR 1, Acute myeloid leukemia 1, Acute myeloid leukemia 1 protein, Aml1 oncogene, CBF b, CBF-alpha-2, CBF-beta, CBFA 2, Core binding factor alpha 2 subunit, Core binding factor beta subunit, Core binding factor runt domain alpha subunit 2, Core-binding factor subunit alpha-2, Core-binding factor subunit beta, Core-binding factor, beta subunit (CBFB), transcript variant 2, DINB protein, DINB1, DINP, DNA damage inducible protein b, DNA polymerase kappa, DNase IV, DinB homolog 1 (E. coli), FEN1_HUMAN, Flap endonuclease 1, Flap structure-specific endonuclease 1, HGNC, MF1, Maturation factor 1, OTTHUMP00000108696, OTTHUMP00000108697, OTTHUMP00000108699, OTTHUMP00000108700, OTTHUMP00000108702, Oncogene AML-1, PEA 2, PEA2-alpha B, PEA2-beta, PEBB_HUMAN, PEBP 2B, PEBP2-alpha B, PEBP2-beta, PEBP2A2, PEBP2aB, POLK_HUMAN, POLQ, Polymerase (DNA directed) kappa, Polyomavirus enhancer-binding protein 2 alpha B subunit, Polyomavirus enhancer-binding protein 2 beta subunit, RUNX1_HUMAN, Rad2, Run1, Runt-related transcription factor 1, SL3 3 enhancer factor 1 beta subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor alpha B subunit, SL3/AKV core-binding factor beta subunit, alpha subunit core binding factor, hFEN-1, polymerase, DNA, kappa
- Chemical Structure
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Chemical Structure - HBDDE, PKCalpha and PKCgamma inhibitor (AB141573)
2D chemical structure image of ab141573, HBDDE, PKCalpha and PKCgamma inhibitor
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補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FEN1 DNA Polymerase Kappa RUNX1/AML1 and CBFb play significant roles in genetic stability and gene regulation. FEN1 is involved in the DNA replication machinery ensuring the integrity of the genome. DNA Polymerase Kappa is part of the translesion DNA synthesis (TLS) pathway that helps bypass lesions on the DNA strand allowing replication to continue. RUNX1/AML1 as a transcription factor partners with CBFb to control vital processes such as blood cell differentiation. They participate in a larger complex known as the Core Binding Factor (CBF) essential for regulating gene expression during development.
Pathways
FEN1 and DNA Polymerase Kappa operate in the DNA repair and replication machinery where FEN1 associates with proteins like proliferating cell nuclear antigen (PCNA). RUNX1/AML1 and CBFb significantly contribute to the TGF-beta signaling pathway influencing cell proliferation and differentiation. These pathways integrate various proteins like SMADs for TGF-beta signaling to maintain cellular homeostasis and respond to developmental signals.
文献 (2)
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Molecular and cellular biochemistry 456:167-178 PubMed30739223
2019
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Unspecified reactive species
Cell reports 15:1728-42 PubMed27184844
2016
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Unspecified reactive species
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