JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141573

HBDDE, PKCalpha and PKCgamma inhibitor

HBDDE, PKCalpha and PKCgamma inhibitor

Be the first to review this product! Submit a review

|

(2 Publications)

MW 338.31 Da, Purity >97%. PKCα and PKCγ inhibitor (IC50 values are 43 and 50 μM respectively). δ, βI and βII isotypes are not affected. Inducer of apoptosis. Active in vivo.

別名を表示する

AML 1, AML1 EVI 1, AML1 EVI 1 fusion protein, AMLCR 1, Acute myeloid leukemia 1, Acute myeloid leukemia 1 protein, Aml1 oncogene, CBF b, CBF-alpha-2, CBF-beta, CBFA 2, Core binding factor alpha 2 subunit, Core binding factor beta subunit, Core binding factor runt domain alpha subunit 2, Core-binding factor subunit alpha-2, Core-binding factor subunit beta, Core-binding factor, beta subunit (CBFB), transcript variant 2, DINB protein, DINB1, DINP, DNA damage inducible protein b, DNA polymerase kappa, DNase IV, DinB homolog 1 (E. coli), FEN1_HUMAN, Flap endonuclease 1, Flap structure-specific endonuclease 1, HGNC, MF1, Maturation factor 1, OTTHUMP00000108696, OTTHUMP00000108697, OTTHUMP00000108699, OTTHUMP00000108700, OTTHUMP00000108702, Oncogene AML-1, PEA 2, PEA2-alpha B, PEA2-beta, PEBB_HUMAN, PEBP 2B, PEBP2-alpha B, PEBP2-beta, PEBP2A2, PEBP2aB, POLK_HUMAN, POLQ, Polymerase (DNA directed) kappa, Polyomavirus enhancer-binding protein 2 alpha B subunit, Polyomavirus enhancer-binding protein 2 beta subunit, RUNX1_HUMAN, Rad2, Run1, Runt-related transcription factor 1, SL3 3 enhancer factor 1 beta subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor alpha B subunit, SL3/AKV core-binding factor beta subunit, alpha subunit core binding factor, hFEN-1, polymerase, DNA, kappa

1 Images
Chemical Structure - HBDDE, PKCalpha and PKCgamma inhibitor (AB141573)
  • Chemical Structure

Lab

Chemical Structure - HBDDE, PKCalpha and PKCgamma inhibitor (AB141573)

2D chemical structure image of ab141573, HBDDE, PKCalpha and PKCgamma inhibitor

Key facts

CAS番号

154675-18-0

精製度

>97%

分子量

338.31 Da

分子式

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>8</sub>O<sub>8</sub>

PubChem

3568

由来

Synthetic

溶解性

Soluble in DMSO to 50 mM

Soluble in ethanol to 25 mM (with warming)

化学名

5-(Methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol

生物学的記述

PKCα and PKCγ inhibitor (IC50 values are 43 and 50 μM respectively). δ, βI and βII isotypes are not affected. Inducer of apoptosis. Active in vivo.

Canonical smiles

COCC1=CC(=C(C(=C1C2=C(C(=C(C=C2COC)O)O)O)O)O)O

InChi

InChI=1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3

InChiKey

NEBCAMAQXZIVRE-UHFFFAOYSA-N

IUPAC名

5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The FEN1 (flap endonuclease 1) DNA Polymerase Kappa (POLK) RUNX1 (runt-related transcription factor 1) also known as AML1 and Core Binding Factor Beta (CBFb) proteins perform key mechanical functions in cells. FEN1 a 42 kDa protein acts in DNA replication and repair by removing 5' overhangs during flap structure processing. DNA Polymerase Kappa facilitates DNA synthesis across lesions and is less accurate leading to lesion bypass and is expressed ubiquitously. RUNX1/AML1 along with CBFb forms part of a transcription factor complex that regulates expression of genes important for hematopoiesis. RUNX1 is predominantly expressed in hematopoietic cells while CBFb stabilizes RUNX1-DNA binding.
Biological function summary

FEN1 DNA Polymerase Kappa RUNX1/AML1 and CBFb play significant roles in genetic stability and gene regulation. FEN1 is involved in the DNA replication machinery ensuring the integrity of the genome. DNA Polymerase Kappa is part of the translesion DNA synthesis (TLS) pathway that helps bypass lesions on the DNA strand allowing replication to continue. RUNX1/AML1 as a transcription factor partners with CBFb to control vital processes such as blood cell differentiation. They participate in a larger complex known as the Core Binding Factor (CBF) essential for regulating gene expression during development.

Pathways

FEN1 and DNA Polymerase Kappa operate in the DNA repair and replication machinery where FEN1 associates with proteins like proliferating cell nuclear antigen (PCNA). RUNX1/AML1 and CBFb significantly contribute to the TGF-beta signaling pathway influencing cell proliferation and differentiation. These pathways integrate various proteins like SMADs for TGF-beta signaling to maintain cellular homeostasis and respond to developmental signals.

RUNX1/AML1 and CBFb have strong connections to acute myeloid leukemia (AML) where mutations or translocations disrupt normal function leading to unchecked cell proliferation. RUNX1's alterations are closely related to familial platelet disorder emphasizing its role in hematopoiesis. FEN1 mutations can lead to genomic instabilities linked to cancer. DNA Polymerase Kappa's lesion bypass can sometimes result in mutagenesis linking it to cancer susceptibility. The interaction of these proteins with pathways emphasizes their role in either promoting disease when dysregulated or maintaining health when functioning properly.

製品プロトコール

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular and cellular biochemistry 456:167-178 PubMed30739223

2019

Phospho-substrate profiling of Epac-dependent protein kinase C activity.

Applications

Unspecified application

Species

Unspecified reactive species

Diana J Goode,Derek C Molliver

Cell reports 15:1728-42 PubMed27184844

2016

An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.

Applications

Unspecified application

Species

Unspecified reactive species

Mehran Najibi,Sid Ahmed Labed,Orane Visvikis,Javier Elbio Irazoqui
View all publications

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com