GppNHp, Non-hydrolyzable GTP analog (ab146659)
Key features and details
- Non-hydrolyzable GTP analog
- CAS Number: 64564-03-0
- Purity: > 95%
Soluble in water to 75 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
GppNHp, Non-hydrolyzable GTP analog -
製品の詳細
Non-hydrolyzable GTP analog -
精製度
> 95% -
CAS 番号
64564-03-0 -
構造式
製品の特性
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体系名
[[(2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate tetralithium
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分子量
545.93 -
分子式
C10H13Li4N6O13P3 -
PubChem 登録番号
136494784 -
保存方法
Shipped on Dry Ice. Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 75 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Li+].[Li+].[Li+].[Li+].C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(NP(=O)([O-])[O-])[O-])O)O)N=C(NC2=O)N -
由来
Synthetic
画像
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Chemical Structure - GppNHp, Non-hydrolyzable GTP analog (ab146659)2D chemical structure image of ab146659, GppNHp, Non-hydrolyzable GTP analog
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (7)
ab146659 は 7 報の論文で使用されています。
- Lattao R et al. Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins. Dev Cell N/A:N/A (2021). PubMed: 33725482
- Wandel MP et al. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nat Immunol 21:880-891 (2020). PubMed: 32541830
- Kutsch M et al. Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions. EMBO J 39:e104926 (2020). PubMed: 32510692
- English JG et al. VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. Cell 178:748-761.e17 (2019). PubMed: 31280962
- Kanie T & Jackson PK Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP. Bio Protoc 8:N/A (2018). PubMed: 29951569
- Ivanova AA et al. Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF). J Biol Chem 292:11091-11108 (2017). PubMed: 28487361
- Kanie T et al. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Dev Cell 42:22-36.e12 (2017). PubMed: 28625565
