GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)
Key features and details
- Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist.
- CAS Number: 133052-90-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
GF 109203X (Bisindolylmaleimide i), PKC inhibitor -
製品の詳細
Potent, selective PKC inhibitor. Potent GSK-3 inhibitor. Potent 5-HT3 antagonist. -
別名
- Bisindolylmaleimide I
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精製度
> 98% -
CAS 番号
133052-90-1 -
構造式
製品の特性
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体系名
3-[1-[3-(Dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione -
分子量
412.48 -
分子式
C25H24N4O2 -
PubChem 登録番号
2396 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 -
由来
Synthetic
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研究分野
画像
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Chemical Structure - GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)2D chemical structure image of ab144264, GF 109203X (Bisindolylmaleimide i), PKC inhibitor
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Functional Studies - GF 109203X (Bisindolylmaleimide i), PKC inhibitor (ab144264)1.5 x 10e7 THP-1 cells were incubated with 100 nM GF 109203X (ab144264) or Ro 31-8220 mesylate (ab120374) for 30 minutes prior to activation with 10 µg x mL-1 PMA (Sigma) for 4 hours. Control cells were left without inhibitors or PMA. Cells were lysed in 1 mL of lysis buffer, and 30 µL were tested for PKC activity (duplicates; +/- SD).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab144264 は 3 報の論文で使用されています。
- Wu K et al. Activity- and sleep-dependent regulation of tonic inhibition by Shisa7. Cell Rep 34:108899 (2021). PubMed: 33761345
- Du Y et al. Kv1.5 channels are regulated by PKC-mediated endocytic degradation. J Biol Chem 296:100514 (2021). PubMed: 33676894
- Sutherland-Deveen ME et al. Differential Regulation of Human Ether-à-Go-Go-Related Gene (hERG) Current and Expression by Activation of Protein Kinase C. Mol Pharmacol 96:1-12 (2019). PubMed: 31015282