Geldanamycin-FITC, fluorescent labelled HSP90 inhibitor (ab141589)
Key features and details
- Potent fluorescent labelled-HSP90 inhibitor
- CAS Number: 30562-34-6
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Geldanamycin-FITC, fluorescent labelled HSP90 inhibitor -
製品の詳細
Potent fluorescent labelled-HSP90 inhibitor -
生理活性の詳細
Potent fluorescent labelled-HSP90 inhibitor for in vitro and in vivo use. Geldanamycin from Streptomyces hygroscopicus. -
精製度
> 98% -
CAS 番号
30562-34-6 -
構造式
製品の特性
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分子量
1034.20 -
分子式
C55H63N5O13S -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
NC(=O)O[C@H]1C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=6C(=O)C(NC(=O)C(C)=CC=C[C@@H]1OC)=CC(=O)C=6NCCCCCCNC(=S)Nc5ccc(C=2c4ccc(O)cc4OC3=CC(=O)C=CC=23)c(c5)C(=O)O -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Geldanamycin-FITC, fluorescent labelled HSP90 inhibitor (ab141589)2D chemical structure image of ab141589, Geldanamycin-FITC, fluorescent labelled HSP90 inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (5)
ab141589 は 5 報の論文で使用されています。
- Pan X et al. Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy. Molecules 27:N/A (2022). PubMed: 36080326
- Li Z et al. Synthesis and biological evaluation of geldanamycin-ferulic acid conjugate as a potent Hsp90 inhibitor. RSC Adv 9:42509-42515 (2019). PubMed: 35542888
- Geng K et al. Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs. Eur J Med Chem 152:76-86 (2018). PubMed: 29698859
- Zhang C et al. Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors. Eur J Med Chem 125:315-326 (2017). PubMed: 27688186
- Li Z et al. Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors. Chem Biol Drug Des 85:181-8 (2015). PubMed: 24903735
