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AB120607

GBR 12909 dihydrochloride, Dopamine transport inhibitor

GBR 12909 dihydrochloride, Dopamine transport inhibitor

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MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
2 Images
Immunocytochemistry/ Immunofluorescence - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)

ab65783 staining NR2B in SKNSH cells treated with GBR 12909 dihydrochloride (ab120607), by ICC/IF. Decrease in NR2B expression correlates with increased concentration of GBR 12909 dihydrochloride, as described in literature.
The cells were incubated at 37°C for 10 minutes in media containing different concentrations of ab120607 (GBR 12909 dihydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab65783 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)
  • Chemical Structure

Lab

Chemical Structure - GBR 12909 dihydrochloride, Dopamine transport inhibitor (AB120607)

2D chemical structure image of ab120607, GBR 12909 dihydrochloride, Dopamine transport inhibitor

Key facts

CAS番号

67469-78-7

精製度

>98%

製品の状態

Solid

form

分子量

523.5 Da

分子式

C<sub>2</sub><sub>8</sub>H<sub>3</sub><sub>4</sub>Cl<sub>2</sub>F<sub>2</sub>N<sub>2</sub>O

PubChem

104920

由来

Synthetic

溶解性

Soluble in water to 25 mM (with heating)

Soluble in DMSO to 100 mM (with heating)

化学名

Vanoxerine dihydrochloride

生物学的記述

Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).

Canonical smiles

C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl

InChi

InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H

InChiKey

MIBSKSYCRFWIRU-UHFFFAOYSA-N

IUPAC名

1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride

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出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
Ambient
長期保存温度
Ambient
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months
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製品プロトコール

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組合せ製品

Biochemicals

AB120574

Bromocriptine mesylate, D2-like dopamine receptor agonist

Chemical Structure - Bromocriptine mesylate, D2-like dopamine receptor agonist (AB120574)

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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

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Primary Antibodies

AB211573

Anti-PLA2R antibody [EPR20483]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLA2R antibody [EPR20483] (AB211573)

  • 0
  • 0
Primary Antibodies

AB205270

Anti-active YAP1 antibody [EPR19812]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-active YAP1 antibody [EPR19812] (AB205270)

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