EX-527, SIRT1 Inhibitor (ab141506)
Key features and details
- Selective SIRT1 Inhibitor
- CAS Number: 49843-98-3
- Purity: > 97%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
EX-527, SIRT1 Inhibitor -
製品の詳細
Selective SIRT1 Inhibitor -
精製度
> 97% -
CAS 番号
49843-98-3 -
構造式
製品の特性
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体系名
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide -
分子量
248.71 -
分子式
C13H13ClN2O -
PubChem 登録番号
5113032 -
保存方法
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
NC(=O)C2CCCc1c3cc(Cl)ccc3nc12 -
由来
Synthetic
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研究分野
画像
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Chemical Structure - EX-527, SIRT1 Inhibitor (ab141506)2D chemical structure image of ab141506, EX-527, SIRT1 Inhibitor
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Functional Studies - EX-527, SIRT1 Inhibitor (ab141506)Time course of SIRT1-substrate deacetylation by recombinant SIRT1 in the presence of EX-527.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (9)
ab141506 は 9 報の論文で使用されています。
- Sarkar A et al. Early loss of endogenous NAD+ following rotenone treatment leads to mitochondrial dysfunction and Sarm1 induction that is ameliorated by PARP inhibition. FEBS J 290:1596-1624 (2023). PubMed: 36239430
- Mao H et al. Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury. Oxid Med Cell Longev 2022:7444430 (2022). PubMed: 35126819
- Zhang J et al. Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways. J Food Biochem 46:e14463 (2022). PubMed: 36314441
- Chen J et al. Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model. Prostate 81:1179-1190 (2021). PubMed: 34418127
- Ruan C et al. Neuroprotective effects of metformin on cerebral ischemia-reperfusion injury by regulating PI3K/Akt pathway. Brain Behav 11:e2335 (2021). PubMed: 34473417
- Zhan H et al. Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets. Oxid Med Cell Longev 2021:8889195 (2021). PubMed: 34646427
- Zhang J et al. N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation. J Diabetes Res 2020:1080152 (2020). PubMed: 32280711
- Wu Y et al. Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy. Mol Med Rep 22:2219-2226 (2020). PubMed: 32705226
- Liu SP et al. Secukinumab attenuates reactive astrogliosis via IL-17RA/(C/EBPß)/SIRT1 pathway in a rat model of germinal matrix hemorrhage. CNS Neurosci Ther N/A:N/A (2019). PubMed: 31020769