JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141282

Dienogest, Steroidal progesterone

Dienogest, Steroidal progesterone

Be the first to review this product! Submit a review

|

(1 Publication)

MW 311.4 Da, Purity >99%. Steroidal progesterone. Non-ethinylated progestin structurally related to testosterone. Anti-androgenic and antiproliferative effects in vitro.
2 Images
Functional Studies - Dienogest, Steroidal progesterone (AB141282)
  • FuncS

Unknown

Functional Studies - Dienogest, Steroidal progesterone (AB141282)

ab16895 staining MDM2 in MCF7 cells treated with dienogest (ab141282), by ICC/IF. Decrease in MDM2 expression correlates with increased concentration of dienogest, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab141282 (dienogest) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16895 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Dienogest, Steroidal progesterone (AB141282)
  • Chemical Structure

Lab

Chemical Structure - Dienogest, Steroidal progesterone (AB141282)

2D chemical structure image of ab141282, Dienogest, Steroidal progesterone

Key facts

CAS番号

65928-58-7

精製度

>99%

製品の状態

Solid

form

分子量

311.4 Da

分子式

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>5</sub>NO<sub>2</sub>

PubChem

68861

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

化学名

Dienogest

生物学的記述

Steroidal progesterone. Non-ethinylated progestin structurally related to testosterone. Anti-androgenic and antiproliferative effects in vitro.

Canonical smiles

CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(CC#N)O

Isomeric smiles

C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC#N)O

InChi

InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1

InChiKey

AZFLJNIPTRTECV-FUMNGEBKSA-N

IUPAC名

2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile

style
left-column

組合せ製品

Biochemicals

AB120657

17beta-Estradiol, Selective agonist of ER receptor

Functional Studies - 17beta-Estradiol, Selective agonist of ER receptor (AB120657)

  • 0
  • 0
Assay Kits

AB204715

Tyrosinase Inhibitor Assay Kit (Colorimetric)

Functional Studies (Neut/Block) - Tyrosinase Inhibitor Assay Kit (Colorimetric) (AB204715)

  • 0
  • 0
Biochemicals

AB141252

Progesterone, Endogenous progesterone receptor agonist

Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)

  • 0
  • 0
Proteins & Peptides

AB152776

Recombinant Human Tyrosinase protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Tyrosinase protein (GST tag N-Terminus) (AB152776)

  • 0
  • 0
style
left-column
style
left-column

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

|

Toxic, refer to SDS for further information.

style
left-column
style
left-column
style
left-column

製品プロトコール

style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Fertility and sterility 104:655-64.e1 PubMed26051103

2015

Dienogest enhances autophagy induction in endometriotic cells by impairing activation of AKT, ERK1/2, and mTOR.

Applications

Unspecified application

Species

Unspecified reactive species

JongYeob Choi,MinWha Jo,EunYoung Lee,Dong-Yun Lee,DooSeok Choi
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com