Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog (ab144327)
Key features and details
- Stable, cell-permeable analog of pifithrin-α. p53 inhibitor
- CAS Number: 511296-88-1
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog -
製品の詳細
Stable, cell-permeable analog of pifithrin-α. p53 inhibitor -
生理活性の詳細
Stable, cell-permeable analog of pifithrin-α (ab120478). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Potent STAT6 transcriptional inhibitor. Active in vivo and in vitro.
See similar compound -
精製度
> 98% -
CAS 番号
511296-88-1 -
構造式
製品の特性
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体系名
2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide -
分子量
348.28 -
分子式
C16H16N2S.HBr -
PubChem 登録番号
11515812 -
保存方法
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
溶解性
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog (ab144327)2D chemical structure image of ab144327, Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab144327 は論文での使用が確認できていません。
