CRANAD-2, Near-infrared Amyloid-beta fluorescent probe

Key facts

CAS番号

1193447-34-5

精製度

>98%

製品の状態

Solid

form

分子量

410.3 Da

分子式

C₂₃H₂₅BF₂N₂O₂

PubChem

90488972

由来

Synthetic

溶解性

Soluble in DMSO to 5 mM (with warming)

化学名

Cranad-2

生物学的記述

Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (K_d = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more

Canonical smiles

[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F

Isomeric smiles

[B-]1(OC(=C/C(=C/C=C2C=CC(=[N+](C)C)C=C2)/O1)/C=C/C3=CC=C(C=C3)N(C)C)(F)F

InChi

InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3

InChiKey

PVXQJYXODFZTBR-UHFFFAOYSA-N

IUPAC名

[4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difluoro-1,3-dioxa-2-boranuidacyclohex-5-en-4-ylidene]ethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium