Congo Red, Amyloid fibril-binding dye
Congo Red, Amyloid fibril-binding dye
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MW 696.7 Da, Purity >98%. Amyloid fibril-binding dye. Caspase inhibitor. Red shifts on aggregation and binding to amyloid fibrils. Blue shifts on binding to cellulose. Shows apple green birefringence under polarized light in the presence of amyloid fibrils. Inhibits Fib-beta A neurotoxicity.
別名を表示する
A BETA, A4 amyloid protein, A4_HUMAN, AAA, ABPP, AD1, AICD-50, AICD-57, AICD-59, AID(50), AID(57), AID(59), APP, APPI, ATX, ATX X, Acetyl CoA choline O acetyltransferase, Acetyl CoA:choline O acetyltransferase, Alzheimer disease amyloid protein, Amyloid beta (A4) precursor protein, Amyloid beta A4 protein, Amyloid beta protein, Amyloid intracellular domain 50, Amyloid intracellular domain 57, Amyloid intracellular domain 59, Amyloid precursor protein, Autotaxin, Autotaxin t, Beta-APP40, Beta-APP42, Beta-amyloid precursor protein, C31, CHOACTase, CLAT_HUMAN, CMS1A, CMS1A2, CTFgamma, CVAP, Cerebral vascular amyloid peptide, ChAT, Choline O acetyltransferase, Choline acetylase, DHFR, DHFRP1, DYR_HUMAN, Dihydrofolate reductase, EC 1.5.1.3, EC 2.3.1.6, ENPP2_HUMAN, Ectonucleotide pyrophosphatase/phosphodiesterase 2, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, Extracellular lysophospholipase D, FLJ26803, Gamma-CTF(50), Gamma-CTF(57), Gamma-CTF(59), LysoPLD, NPP2, OTTHUMP00000019583, OTTHUMP00000019584, PD IALPHA, PDNP2, PN 2, PN-II, Phosphodiesterase I alpha, Phosphodiesterase I/nucleotide pyrophosphatase 2, Plasma lysophospholipase D, PreA4, Protease nexin-II, S-APP-alpha, S-APP-beta, beta-amyloid peptide, choline acetyltransferase, peptidase nexin-II, sAPP
- Chemical Structure
Lab
Chemical Structure - Congo Red, Amyloid fibril-binding dye (AB145645)
2D chemical structure image of ab145645, Congo Red, Amyloid fibril-binding dye
製品の詳細
出荷温度及び保存条件
出荷温度
長期保存温度
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The synthesis of acetylcholine by ChAT is essential for cholinergic neurotransmission influencing muscle activation and several aspects of cognition. ChAT doesn't function as part of a complex acting independently to catalyze the conversion of acetyl-CoA and choline into acetylcholine. In contrast APP undergoes proteolytic processing leading to the formation of amyloid-beta associated with amyloid plaque formation in Alzheimer's disease. DHFR plays an integral role in the reduction of dihydrofolate to tetrahydrofolate critical for synthesizing nucleotides for DNA replication. ENPP2/ATX generates lysophosphatidic acid (LPA) which modulates cell proliferation and migration.
Pathways
ChAT is pivotal in the acetylcholine biosynthesis pathway interacting with other enzymes involved in neurotransmitter cycling such as acetylcholinesterase which breaks down acetylcholine. APP is central to the amyloidogenic and non-amyloidogenic pathways which include secretase-mediated cleavage that can also involve presenilin enzymes. DHFR is part of the folate pathway essential for the de novo synthesis of purine and thymidylate and shares involvement with the enzyme thymidylate synthase. ENPP2/ATX has significant roles in the LPA signaling pathway interacting with LPA receptors which activate various downstream signaling cascades.
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