clasto-Lactacystin beta-lactone, 20S proteasome inhibitor (ab141412)
Key features and details
- Potent, irreversible and cell-permeable 20S proteasome inhibitor
- CAS Number: 154226-60-5
- Purity: > 95%
- Soluble in DMSO to 75 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
clasto-Lactacystin beta-lactone, 20S proteasome inhibitor -
製品の詳細
Potent, irreversible and cell-permeable 20S proteasome inhibitor -
精製度
> 95% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 1710 Clasto-Lactacystin ß-lactone. 1710-100 is the same size as the 100 µg size of ab141412.
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CAS 番号
154226-60-5 -
構造式
製品の特性
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体系名
(1S,2R,5R)-5-[(1S)-1-Hydroxy-2-methylpropyl]-2-methyl-7-oxa-4-azabicyclo[3.2.0]heptane-3,6-dione -
分子量
213.23 -
分子式
C10H15NO4 -
PubChem 登録番号
9794358 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 75 mM and in water to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1C2C(C(=O)O2)(NC1=O)C(C(C)C)O -
由来
Synthetic
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研究分野
画像
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Chemical Structure - clasto-Lactacystin beta-lactone, 20S proteasome inhibitor (ab141412)2D chemical structure image of ab141412, clasto-Lactacystin beta-lactone, 20S proteasome inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab141412 は 2 報の論文で使用されています。
- Bernabo M et al. Memory Destabilization and Reconsolidation Dynamically Regulate the PKM? Maintenance Mechanism. J Neurosci 41:4880-4888 (2021). PubMed: 33888608
- Kajiho H et al. CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. Sci Rep 9:13152 (2019). PubMed: 31511573