Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor (ab141988)
Key features and details
- Selective cyclooxygenase-2 (COX-2) inhibitor. Non-steroidal anti-inflammatory drug.
- CAS Number: 169590-42-5
- Soluble in DMSO to 25 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor -
製品の詳細
Selective cyclooxygenase-2 (COX-2) inhibitor. Non-steroidal anti-inflammatory drug. -
生理活性の詳細
Selective COX-2 inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Non-steroidal anti-inflammatory drug. Enhances tumor cell apoptosis in vivo. Orally active.
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CAS 番号
169590-42-5 -
構造式
製品の特性
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体系名
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide -
分子量
381.37 -
分子式
C17H14F3N3O2S -
PubChem 登録番号
2662 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 25 mM and in ethanol to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor (ab141988)2D chemical structure image of ab141988, Celecoxib (Celebrex), cyclooxygenase-2 (COX-2) inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab141988 は 4 報の論文で使用されています。
- Dey R & Bishayi B TLR-2 neutralization potentiates microglial M1 to M2 switching by the combinatorial treatment of ciprofloxacin and dexamethasone during S. aureus infection. J Neuroimmunol 344:577262 (2020). PubMed: 32450430
- Harati R et al. Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling. Pharmaceuticals (Basel) 13:N/A (2020). PubMed: 32645833
- Naji S et al. Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2. Cell Physiol Biochem 52:1517-1534 (2019). PubMed: 31120230
- Chen L et al. L161982 alleviates collagen-induced arthritis in mice by increasing Treg cells and down-regulating Interleukin-17 and monocyte-chemoattractant protein-1 levels. BMC Musculoskelet Disord 18:462 (2017). PubMed: 29145862