CCT 018159, Hsp90 ATPase inhibitor (ab146412)
Key features and details
- Selective, cell-permeable Hsp90 ATPase inhibitor
- CAS Number: 171009-07-7
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
CCT 018159, Hsp90 ATPase inhibitor -
製品の詳細
Selective, cell-permeable Hsp90 ATPase inhibitor -
生理活性の詳細
Selective, cell-permeable Hsp90 ATPase inhibitor (IC50 values are 3.2 μM and 6.6 μM for Human Hsp90 beta and yeast Hsp90 respectively). Exhibits no detectable effects against Human Hsp72 ATPase or topoisomerase II. Shows antiproliferative effects. Upregulates Hsp72 and downregulates c-Raf and cdk4. Antitumor activity is independent of NQO1/DT-diaphorase and P-glycoprotein expression.
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精製度
> 98% -
CAS 番号
171009-07-7 -
構造式
製品の特性
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体系名
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol -
分子量
352.39 -
分子式
C20H20N2O4 -
保存方法
Shipped at 4°C. Store at +4°C. -
溶解性
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
使用に関する注意
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CCc1cc(c(cc1O)O)c2c(c([nH]n2)C)c3ccc4c(c3)OCCO4 -
由来
Synthetic
画像
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Chemical Structure - CCT 018159, Hsp90 ATPase inhibitor (ab146412)2D chemical structure image of ab146412, CCT 018159, Hsp90 ATPase inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab146412 は 3 報の論文で使用されています。
- Dunna NR et al. Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target. Curr Top Med Chem 15:57-64 (2015). PubMed: 25579569
- Beloueche-Babari M et al. Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition. Oncotarget 1:185-97 (2010). PubMed: 21037799
- Sharp SY et al. In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res 67:2206-16 (2007). PubMed: 17332351