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AB141354

Carbamoylcholine chloride (Carbachol), Cholinergic agonist

Carbamoylcholine chloride (Carbachol), Cholinergic agonist

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(2 Publications)

MW 182.65 Da. Non-selective cholinergic agonist. Cholinesterase resistant. Blocks apoptosis. Achieve your results faster with highly validated, pure and trusted compounds.

別名を表示する

7TM receptor, 7nAChR, A4 nicotinic receptor, ACEE, ACES_HUMAN, ACH 4, ACH10_HUMAN, ACHA2_HUMAN, ACHA4_HUMAN, ACHA7_HUMAN, ACHB2_HUMAN, ACHB4_HUMAN, ACHN, ACM2_HUMAN, ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, ARACHE, Acetylcholine receptor alpha 4 neural, Acetylcholine receptor beta 2 neural, Acetylcholine receptor muscarinic 5, Acetylcholine receptor neuronal nicotinic alpha 4 subunit, Acetylcholine receptor, muscarinic, 2, Acetylcholine receptor, neuronal nicotinic, alpha-10 subunit, Acetylcholinesterase, Acra 4, Acra7, Acrb 2, Alpha 10 nAChR, Alpha4 nAChR, Apoptosis related acetylcholinesterase, BFNC, Beta-3 subunit precursor, CHKM5MR, CHRM 2, CHRM 3, CHRM1, CHRNA 4, CHRNA7, CHRNA7-2, CM2, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 2, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Cholinergic receptor nicotinic alpha 10, Cholinergic receptor nicotinic alpha 2, Cholinergic receptor nicotinic alpha 4, Cholinergic receptor nicotinic alpha 9, Cholinergic receptor nicotinic alpha polypeptide 4, Cholinergic receptor nicotinic alpha polypeptide 9, Cholinergic receptor nicotinic beta 2, Cholinergic receptor nicotinic beta 4, Cholinergic receptor nicotinic beta polypeptide 2, Cholinergic receptor nicotinic beta polypeptide 2 neuronal, Cholinergic receptor nicotinic beta polypeptide 4, Cholinergic receptor, muscarinic 2, cardiac, Cholinergic receptor, muscarinic 2, isoform a, Cholinergic receptor, muscarinic 2a, Cholinergic receptor, neuronal nicotinic, alpha polypeptide 10, Cholinergic receptor, nicotinic, alpha polypeptide 10, Chrm 4, Chrm 5, Chrnb2, EBN, EBN 1, EFNL 3, EGBRS, FLJ43243, HM 2, HM 3, HM 4, HM 5, HM1, HSA243342, M2 muscarinic receptor, M2-mAChR, M3 muscarinic receptor, M4, M5R, MGC120006, MGC120007, MGC142109, MGC142135, MGC41838, Muscarinic M2 receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, N-ACHE, NACHR, NACHR alpha 9, NACHR alpha-10, NACHRA10, NACHRA7, NACHRA9, NACRA 4, Neuronal acetylcholine receptor protein, Neuronal acetylcholine receptor protein beta 2 chain precursor, Neuronal acetylcholine receptor protein subunit alpha 10, Neuronal acetylcholine receptor protein subunit alpha 2, Neuronal acetylcholine receptor protein subunit alpha 9 precursor, Neuronal acetylcholine receptor protein subunit beta 2, Neuronal acetylcholine receptor subunit alpha-10, Neuronal acetylcholine receptor subunit alpha-2, Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit alpha-7, Neuronal acetylcholine receptor subunit beta-2, Neuronal acetylcholine receptor subunit beta-4, Neuronal nicotinic acetylcholine receptor alpha 4 subunit, Neuronal nicotinic acetylcholine receptor beta 2, Neuronal nicotinic receptor beta 4 subunit, Nicotinic Acetylcholine Receptor alpha 2, Nicotinic acetylcholine receptor subunit alpha-10, OTTHUMP00000013620, YT, YT blood group, a7 nicotinic acetylcholine receptor, acetylcholine receptor, neuronal nicotinic, alpha-7 subunit, acetylcholine receptor, nicotinic, beta 4 (neuronal), alpha 7 neuronal nicotinic acetylcholine receptor, alpha-7 nicotinic cholinergic receptor subunit, alpha7, b2 nAchR, cholinergic receptor muscarinic 3, cholinergic receptor, neuronal nicotinic, alpha polypeptide 7, cholinergic receptor, nicotinic, alpha 7, cholinergic receptor, nicotinic, alpha 7 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 7, cholinergic receptor, nicotinic, beta 2 (neuronal), chrm2a, m3 muscarinic acetylcholine receptor, m5, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor, nAChRB2, neuronal acetylcholine receptor protein, alpha-7 chain

1 Images
Chemical Structure - Carbamoylcholine chloride (Carbachol), Cholinergic agonist (AB141354)
  • Chemical Structure

Lab

Chemical Structure - Carbamoylcholine chloride (Carbachol), Cholinergic agonist (AB141354)

2D chemical structure image of ab141354, Carbamoylcholine chloride (Carbachol), Cholinergic agonist

Key facts

CAS番号

51-83-2

製品の状態

Solid

form

分子量

182.65 Da

分子式

C<sub>6</sub>H<sub>1</sub><sub>5</sub>N<sub>2</sub>O<sub>2</sub>.Cl

PubChem

5831

由来

Synthetic

溶解性

Soluble in water to 100 mM

化学名

Carbachol

生物学的記述

Non-selective cholinergic agonist. Cholinesterase resistant. Blocks apoptosis.

Canonical smiles

C[N+](C)(C)CCOC(=O)N.[Cl-]

InChi

InChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H

InChiKey

AIXAANGOTKPUOY-UHFFFAOYSA-N

IUPAC名

2-carbamoyloxyethyl(trimethyl)azanium;chloride

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出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
Ambient
長期保存温度
Ambient
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Acetylcholinesterase also known as AChE is an enzyme with a molecular mass typically around 68 kDa. It is mainly expressed in the neuromuscular junctions and central nervous system where it plays a critical role in breaking down acetylcholine into acetate and choline stopping the signal transmission across a synapse. The target also includes muscarinic acetylcholine receptors such as CHRM1 CHRM2 CHRM3 CHRM4 and CHRM5 as well as nicotinic acetylcholine receptors subunits like CHRNA4 CHRNA7 CHRNB2 CHRNA10 CHRNA2 CHRNB3 CHRNB4 and CHRNA9. These receptors are expressed in various tissues including the brain heart and other peripheral organs.
Biological function summary

These proteins and complexes play significant roles in mediating cholinergic transmission. The muscarinic receptors are integral to G-protein coupled receptor complexes modulating responses such as cardiac rhythm or glandular secretion. Nicotinic receptors on the other hand form ion channels that regulate neurotransmitter release and are important in cognitive processes and neuromuscular function. Acetylcholinesterase assists in clearing acetylcholine from synaptic clefts to reset the signaling pathway and prevent continuous stimulation making this enzyme vital in synaptic signaling.

Pathways

Acetylcholinesterase and the cholinergic receptors are part of the cholinergic signaling pathway and neurotransmitter pathway. These pathways are essential for various physiological functions including muscle contraction and memory formation. Nicotinic acetylcholine receptor subunits like CHRNA4 and CHRNB2 are known for their roles in the dopaminergic pathway which links them to dopamine metabolism and transporters. Additionally the muscarinic receptors CHRM1 and CHRM5 integrate into the signal transduction and contribute to intracellular calcium regulation and MAP kinase activity.

Dysfunction in these targets can relate to Alzheimer's disease and myasthenia gravis. Alzheimer's is associated with a decrease in acetylcholinesterase activity impacting synaptic transmission and memory. Muscarinic acetylcholine receptors particularly CHRM2 and CHRM3 also have links to neurodegenerative processes. Nicotinic receptors like CHRNA4 and CHRNB4 may play roles in addiction and mood disorders by influencing dopaminergic activity. Understanding how these targets interact can illuminate their contributions to such diseases and potential therapeutic interventions.
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製品プロトコール

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 180:2550-2576 PubMed37198101

2023

BQ788 reveals glial ET receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus.

Applications

Unspecified application

Species

Unspecified reactive species

Elvio Mazzotta,Iveta Grants,Egina Villalobos-Hernandez,Samhita Chaudhuri,Jonathon L McClain,Luisa Seguella,Derek M Kendig,Bryan A Blakeney,Srinivasa K Murthy,Reiner Schneider,Patrick Leven,Sven Wehner,Alan Harzman,John R Grider,Brian D Gulbransen,Fedias L Christofi

eLife 9: PubMed32073397

2020

Presynaptic GABA receptors functionally uncouple somatostatin interneurons from the active hippocampal network.

Applications

Unspecified application

Species

Unspecified reactive species

Sam A Booker,Harumi Harada,Claudio Elgueta,Julia Bank,Marlene Bartos,Akos Kulik,Imre Vida
View all publications
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