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AB120723

Baicalein, Lipoxygenase inhibitor.

Baicalein, Lipoxygenase inhibitor.

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MW 270.24 g/mol, Purity >98%. Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.
2 Images
Immunocytochemistry/ Immunofluorescence - Baicalein, Lipoxygenase inhibitor. (AB120723)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Baicalein, Lipoxygenase inhibitor. (AB120723)

ab51608 staining HIF1α in HepG2 cells treated with baicalein (ab120723), by ICC/IF. Increase in HIF1α expression correlates with increased concentration of baicalein as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120723 (baicalein) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51608 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - Baicalein, Lipoxygenase inhibitor. (AB120723)
  • Chemical Structure

Lab

Chemical Structure - Baicalein, Lipoxygenase inhibitor. (AB120723)

2D chemical structure image of ab120723, Baicalein, Lipoxygenase inhibitor.

Key facts

CAS番号

491-67-8

精製度

>98%

製品の状態

Solid

form

分子量

270.24 g/mol

分子式

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>0</sub>O<sub>5</sub>

由来

Synthetic

溶解性

Soluble in DMSO to 50 mM

生物学的記述

Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.

IUPAC名

5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one

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出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months
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製品プロトコール

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組合せ製品

Primary Antibodies

AB179483

Anti-HIF-1 alpha antibody [EPR16897]

RabMAb|Advanced Validation|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-HIF-1 alpha antibody [EPR16897] (AB179483)

  • 4
  • 9
Biochemicals

AB144206

Bisindolylmaleimide II, PKC inhibitor

Chemical Structure - Bisindolylmaleimide II, PKC inhibitor (AB144206)

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  • 0
Biochemicals

AB144422

CAY10585, HIF-1alpha inhibitor

  • 0
  • 0
Proteins & Peptides

AB233665

Recombinant human TLR4 protein (Active)

  • 0
  • 0

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