Amylin (human), Endogenous peptide (ab142398)
Key features and details
- Endogenous peptide. Potent amylin, calcitonin, CGRP and adrenomedullin receptor agonist.
- CAS Number: 122384-88-7
- Purity: > 95%
- Soluble in water (5 mg/mL)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Amylin (human), Endogenous peptide -
製品の詳細
Endogenous peptide. Potent amylin, calcitonin, CGRP and adrenomedullin receptor agonist. -
別名
- Islet amyloid polypeptide (IAPP)
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生理活性の詳細
Endogenous peptide. Potent amylin, calcitonin (EC50 = 0.67 nM), CGRP and adrenomedullin receptor agonist. Potently inhibits insulin-stimulated glucose uptake in skeletal muscle cells (IC50 = 12 pM). Implicated in type II diabetes. Active in vivo. Rat (ab142399) and feline (ab142397) amylin also available. -
精製度
> 95% -
CAS 番号
122384-88-7 -
構造式
製品の特性
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分子量
3903.40 -
分子式
C165H261N51O55S2 -
配列
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (Modifications: C-terminal amide; Disulfide bonds: 2-7) -
PubChem 登録番号
16132430 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water (5 mg/mL) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
画像
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Chemical Structure - Amylin (human), Endogenous peptide (ab142398)2D chemical structure image of ab142398, Amylin (human), Endogenous peptide
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (3)
ab142398 は 3 報の論文で使用されています。
- Majumder P et al. A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes. Biochem J 478:3297-3317 (2021). PubMed: 34409981
- Majumder P et al. Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer's disease and type 2 diabetes. Mol Cell Biochem 459:171-182 (2019). PubMed: 31154588
- Suzuki H & Yamamoto T Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata. Tissue Cell 46:535-9 (2014). PubMed: 25458814
