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AB141314

AM580, RARalpha agonists

AM580, RARalpha agonists

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MW 351.4 Da, Purity >98%. Selective RARα agonists (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo..

別名を表示する

1 25 dihydroxyvitamin D3 receptor, 25-dihydroxyvitamin D3 receptor, AIS, ANDR_HUMAN, AR, AR8, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Atherosclerosis, susceptibility to, included, BAR, Bile acid receptor, CHNG1, DHTR, DKFZp686N23123, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen resistance, included, FLJ00280, FLJ00318, FLJ16020, FLJ16733, Farnesoid X-activated receptor, Farnesol receptor HRR-1, HAP, HBV-activated protein, HDL cholesterol, augmented response of, to hormone replacement, included, HRR 1, HUMARA, HYSP1, IMD42, KD, Kennedy disease (KD), LGR 3, MGC102720, MGC129539, MGC75129, Member 1, Myocardial infarction, susceptibility to, included, NF-E2-related factor 2, NF2L2_HUMAN, NR1B1, NR1B2, NR1B3, NR1F3, NR1I1, NR2B1, NR3A1, NR3A2, NR3C4, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group B member 2, Nuclear receptor subfamily 1 group B member 3, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 1 group I member 1, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, PPP1R163, Protein phosphatase 1, regulatory subunit 163, RAR, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-alpha, RAR-beta, RAR-epsilon, RAR-gamma, RAR-related orphan receptor C, RARA_HUMAN, RARB_HUMAN, RARC, RARG_HUMAN, RARalpha1, RIP 14, RNESTROR, RORG_HUMAN, RRB2, RXR alpha1, RXR-interacting protein 14, RXRA_HUMAN, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor RXR-alpha, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, Retinoic acid receptor beta, Retinoic acid receptor beta 2, Retinoic acid receptor beta 4, Retinoic acid receptor beta 5, Retinoic acid receptor beta polypeptide, Retinoic acid receptor gamma 2, Retinoic acid receptor, gamma, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, Retinoid X receptor-interacting protein 14, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SMAX1, Seven transmembrane helix receptor, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, TOR, TSH Receptor, TSHR_HUMAN, Testicular Feminization (TFM), Thyroid adenoma hyperfunctioning, Thyroid carcinoma with thyrotoxicosis, Thyroid stimulating hormone receptor, isoform 2, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, Thyrotropin receptor I, hTSHR I, VDR_HUMAN, Vitamin D (1,25- dihydroxyvitamin D3) receptor, Vitamin D hormone receptor, Vitamin D nuclear receptor variant 1, Vitamin D receptor, Vitamin D3 receptor, androgen receptor splice variant 4b, erythroid derived 2, hTSHR I, like 2, nuclear factor erythroid 2 like 2

1 Images
Chemical Structure - AM580, RARalpha agonists (AB141314)
  • Chemical Structure

Lab

Chemical Structure - AM580, RARalpha agonists (AB141314)

2D chemical structure image of ab141314, AM580, RARalpha agonists

Key facts

CAS番号

102121-60-8

精製度

>98%

製品の状態

Solid

form

分子量

351.4 Da

分子式

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>5</sub>NO<sub>3</sub>

PubChem

2126

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

化学名

4-{[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid

生物学的記述

Selective RARα agonists (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo.

Canonical smiles

CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C

InChi

InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

InChiKey

SZWKGOZKRMMLAJ-UHFFFAOYSA-N

IUPAC名

4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Retinoic Acid Receptor gamma (RARG) Vitamin D Receptor (VDR) and Estrogen Receptor (ER) are members of the nuclear receptor superfamily acting as transcription factors regulating gene expression. Known by other names these receptors are pivotal in various physiological functions. RARG's molecular mass is approximately 54 kDa while others such as VDR weigh around 48 kDa. These receptors show diverse expression patterns; RARG is found in the skin and immune cells VDR expresses in bones and intestines and ER is notably present in breast tissue. TSH Receptor (TSH-R) operates in thyroid gland while Androgen Receptor (AR) finds expression mostly in prostate tissue. Retinoic Acid Receptor alpha (RARA) and beta (RARB) share similar functional roles with RXRA but each has unique tissue-specific patterns of expression. ROR gamma and Nrf2 also play key roles as transcriptional regulators in immune and oxidative stress responses respectively.
Biological function summary

These nuclear receptors influence major body systems by interacting with hormones or vitamins to regulate gene transcription. They form dimeric or heterodimeric complexes such as RXRA pairing with retinoic acid receptors. RARG VDR and ER modulate cell differentiation proliferation and apoptosis. TSH-R primarily regulates thyroid hormone synthesis influencing metabolism. AR mediates sexual development and reproductive functions while RORA and RARB partakes in embryonic development. ROR gamma is essential for thymopoiesis an aspect of immune defense. Nrf2 manages cellular antioxidant defense by initiating transcription of protective genes promoting cellular resilience against oxidative stress.

Pathways

These receptors integrate into critical signaling networks affecting multiple cellular processes. The retinoic acid-mediated pathway involves RARG RARA and RXRA influencing gene expression for tissue morphogenesis and homeostasis often linked with RXRA partners like PPARs. Similarly the Vitamin D pathway involves VDR impacting calcium and phosphate metabolism through interaction with proteins like calmodulin. Their involvement extends to immune response regulation and metabolic processes wherein ER components intersect with steroid biosynthesis pathways to modulate reproductive health.

The misregulation of these receptors links to various clinical conditions. RAR malfunctions can result in dermatological disorders and immune diseases. Increased or decreased activity in AR associates with prostate cancer affirming its role in tumorigenesis. RXRA in metabolic syndrome has links with lipid regulation issues when pathways malfunction. VDR's defective signaling connects to osteoporosis through impaired calcium metabolism. Nrf2's defective regulation associates with neurodegenerative diseases and cancer driven by disrupted oxidative stress responses.

製品プロトコール

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