alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (ab120189)
Key features and details
- Endogenous melanocortin receptor agonist
- CAS Number: 581-05-5
- Soluble in water
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist -
製品の詳細
Endogenous melanocortin receptor agonist -
別名
- α-Melanocyte-stimulating hormone
- α-Melanotropin
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生理活性の詳細
Endogenous melanocortin receptor agonist involved in feeding, homeostasis, body weight and inflammation.
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CAS 番号
581-05-5 -
構造式
製品の特性
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分子量
1664.89 -
分子式
C77H109N21O19S -
配列
SYSMEHFRWGKPV (Modifications: N-terminal acetyl; C-terminal amide) -
PubChem 登録番号
16132144 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Peptide Receptors
- Melanocyte Stimulating Hormone
- Agonists
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Biochemicals
- Research Area
- Pain & inflammation
- Peptide Receptors
- Melanocyte Stimulating Hormone
- Agonists
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120189の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
Functional Studies
Use at an assay dependent concentration. |
画像
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Chemical Structure - alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (ab120189)2D chemical structure image of ab120189, alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist
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Functional Studies - alpha-MSH (alpha-Melanocyte-stimulating hormone), Endogenous melanocortin receptor agonist (ab120189)ab24851 staining cAMP in MALME-3M cells treated with α-MSH (ab120189), by ICC/IF. Increase of cAMP correlates with increased concentration of α-MSH as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120189 (α-MSH) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab24851 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab120189 は 4 報の論文で使用されています。
- Deng Q et al. A thalamic circuit facilitates stress susceptibility via melanocortin 4 receptor-mediated activation of nucleus accumbens shell. CNS Neurosci Ther 29:646-658 (2023). PubMed: 36510669
- Urai S et al. Paraneoplastic isolated adrenocorticotropic hormone deficiency revealed after immune checkpoint inhibitors therapy: new insights into anti-corticotroph antibody. Front Immunol 14:1284301 (2023). PubMed: 38035072
- Brami-Cherrier K et al. Botulinum Neurotoxin Type A Directly Affects Sebocytes and Modulates Oleic Acid-Induced Lipogenesis. Toxins (Basel) 14:N/A (2022). PubMed: 36287976
- Löw K et al. A proopiomelanocortin-derived peptide sequence enhances plasma stability of peptide drugs. FEBS Lett 594:2840-2866 (2020). PubMed: 32506501
