Agomelatine, MT1/MT2 agonist and 5-HT2C antagonist

Agomelatine, MT1/MT2 agonist and 5-HT2C antagonist

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MW 243.3 Da, Purity >99%. Potent MT1/MT2 agonist (Ki values are 0.1 and 0.12 nM, respectively). 5-HT2C antagonist (IC50 = 270 nM). Shows antidepressant effects *in vivo*. Orally active.

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5 Hydroxytryptamine 2C receptor, 5-HT-1C, 5-HTR2C, 5-ht-1c receptor, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 2C, 5HT2C_HUMAN, FGQTL2, HTR2C, Htr1c, MEL-1A-R, MEL-1B-R, MR, MT 2 melatonin receptor, MT-1, MTNR 1A, MTR1A_HUMAN, MTR1B_HUMAN, Mel 1b, Mel 1b melatonin receptor, Mel1a melatonin receptor, Mel1a receptor, Mel1b receptor, MelR, Melatonin receptor 1A, Melatonin receptor MEL 1B, Melatonin receptor type 1A, Melatonin receptor type 1B, Mtnr 1b, Serotonin 5-HT-2C receptor, Serotonin receptor 2C, melatonin receptor 1B, serotonin 1c receptor, serotonin 2c receptor