AdipoRon, Adiponectin receptor agonist (ab144867)
Key features and details
- Adiponectin receptor agonist
- CAS Number: 924416-43-3
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
AdipoRon, Adiponectin receptor agonist -
製品の詳細
Adiponectin receptor agonist -
生理活性の詳細
Adiponectin receptor agonist (KD values are 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). AMPK and PPARα signaling activator. Shows antiobesogenic, antidiabetic and cardioprotective effects in vivo. Orally active.
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精製度
> 98% -
CAS 番号
924416-43-3 -
構造式
製品の特性
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体系名
2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide -
分子量
428.52 -
分子式
C27H28N2O3 -
PubChem 登録番号
16307093 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4 -
由来
Synthetic
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研究分野
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
画像
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Chemical Structure - AdipoRon, Adiponectin receptor agonist (ab144867)2D chemical structure image of ab144867, AdipoRon, Adiponectin receptor agonist
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab144867 は 2 報の論文で使用されています。
- Tarkhnishvili A et al. Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice. J Lipid Atheroscler 11:161-177 (2022). PubMed: 35656151
- Wang YT et al. Contribution of transcription factor EB to adipoRon-induced inhibition of arterial smooth muscle cell proliferation and migration. Am J Physiol Cell Physiol 317:C1034-C1047 (2019). PubMed: 31483704