Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (ab143032)
Key features and details
- ROS inhibitor. L-cysteine prodrug. Mucolytic agent.
- CAS Number: 616-91-1
- Purity: > 99%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor -
製品の詳細
ROS inhibitor. L-cysteine prodrug. Mucolytic agent. -
別名
- N-acetyl-L-cysteine
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生理活性の詳細
ROS inhibitor. L-cysteine prodrug. Mucolytic agent. Inhibits viral stimulation by reactive oxygen intermediates. Shows mucolytic, hepatoprotective and antiviral effects in vivo. Orally active.
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精製度
> 99% -
CAS 番号
616-91-1 -
構造式
製品の特性
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体系名
(2R)-2-Acetamido-3-sulfanylpropanoic acid -
分子量
163.19 -
分子式
C5H9NO3S -
PubChem 登録番号
12035 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(=O)N[C@@H](CS)C(=O)O -
由来
Synthetic
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研究分野
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
画像
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Chemical Structure - Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor (ab143032)2D chemical structure image of ab143032, Acetylcysteine (N-Acetyl-L-cysteine), ROS inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (10)
ab143032 は 10 報の論文で使用されています。
- Pan J et al. Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of the Ocular Surface. J Pharmacol Exp Ther 388:506-517 (2024). PubMed: 37442618
- Wu Z et al. Functionalized Hybrid Iron Oxide-Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis. Cancers (Basel) 15:N/A (2023). PubMed: 36831510
- Blengini CS et al. Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B. Aging Cell 20:e13489 (2021). PubMed: 34704342
- Binkley MS et al. KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition. Cancer Discov 10:1826-1841 (2020). PubMed: 33071215
- Yashima H et al. AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. Int J Mol Sci 21:N/A (2020). PubMed: 33291667
- Bradley JR et al. Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma. FASEB Bioadv 2:126-144 (2020). PubMed: 32123862
- Chen T et al. ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury. Neuroscience 416:268-280 (2019). PubMed: 31425734
- Zhuang W et al. MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss. Int J Mol Med 41:3448-3456 (2018). PubMed: 29512778
- Chen YH et al. AGE/RAGE-Induced EMP Release via the NOX-Derived ROS Pathway. J Diabetes Res 2018:6823058 (2018). PubMed: 29744367
- You N et al. COMMD7 activates CXCL10 production by regulating NF-?B and the production of reactive oxygen species. Mol Med Rep 17:6784-6788 (2018). PubMed: 29532873
