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5-Azacytidine, DNMT1 inhibitor (ab142744)

Submit a review Submit a question References (9)
Chemical Structure - 5-Azacytidine, DNMT1 inhibitor (ab142744)

    Key features and details

    • Potent DNMT1 inhibitor. Induces DNA hypomethylation.
    • CAS Number: 320-67-2
    • Purity: > 98%
    • Soluble in water to 50 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    製品の概要

    • 製品名

      5-Azacytidine, DNMT1 inhibitor

    • 製品の詳細

      Potent DNMT1 inhibitor. Induces DNA hypomethylation.

    • 別名

      • 5-AzadCyD
      • Dacogen
      • NSC 102816

    • 精製度

      > 98%

    • CAS 番号

      320-67-2

    • 構造式

      Chemical Structure

    製品の特性

    画像

    • Chemical Structure - 5-Azacytidine, DNMT1 inhibitor (ab142744)
      Chemical Structure - 5-Azacytidine, DNMT1 inhibitor (ab142744)
      2D chemical structure image of ab142744, 5-Azacytidine, DNMT1 inhibitor

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (9)

    ab142744 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab142744 は 9 報の論文で使用されています。

    • Mainwaring OJ  et al. ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors. Nat Commun 14:1221 (2023). PubMed: 36869047
    • Jiang Y  et al. Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17 Differentiation of CD4+T cells Induced by Ovalbumin. Iran J Immunol 20:45-56 (2023). PubMed: 36932919
    • Cossec JC  et al. Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures. Cell Rep 42:112380 (2023). PubMed: 37061916
    • Nam H  et al. Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα. Nat Commun 13:1972 (2022). PubMed: 35418126
    • Schwenzer H  et al. LARP1 isoform expression in human cancer cell lines. RNA Biol 18:237-247 (2021). PubMed: 32286153
    • Alarcón MA  et al. The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer. Int J Mol Sci 21:N/A (2020). PubMed: 33322837
    • Chen J  et al. 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis. Cancer Manag Res 11:9517-9528 (2019). PubMed: 31807076
    • Fort RS  et al. Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth. BMC Cancer 18:127 (2018). PubMed: 29394925
    • Jacobs AH The skin in childhood. Hosp Pract 12:91-112 (1977). PubMed: 142744

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