AB120841

3-Methyladenine, selective PI3K inhibitor

Name: 3-Methyladenine, selective PI3K inhibitor (ab120841) | Abcam
Brand: Abcam Limited
SKU: AB120841
Price: 13000 JPY
Availability: InStock

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(5 Publications)

MW 149.15 g/mol, Purity >98%. Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC₅₀ = 5 mM, rat hepatocytes).

1 Images

Chemical Structure - 3-Methyladenine, selective PI3K inhibitor (AB120841)

Chemical Structure

Lab

Chemical Structure - 3-Methyladenine, selective PI3K inhibitor (AB120841)

2D chemical structure image of ab120841, 3-Methyladenine, selective PI3K inhibitor

Key facts

CAS番号

5142-23-4

精製度

>98%

製品の状態

Solid

form

分子量

149.15 g/mol

分子式

C6H7N5

由来

Synthetic

溶解性

Soluble in DMSO to 50 mM

生物学的記述

Selective PI3K inhibitor. Inhibits the initial phase of the autophagy. Blocks autophagosome formation. Potentiates apoptosis. Inhibits protein degradation (IC₅₀ = 5 mM, rat hepatocytes).

Canonical smiles

NC=2N=CN(C)C1=NC=NC1=2

InChi

InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

InChiKey

FSASIHFSFGAIJM-UHFFFAOYSA-N

IUPAC名

3-Methyl-3H-purin-6-amine

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Refer to SDS for further information.

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Nutrients 15: PubMed37630743

2023

Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics.

Applications

Unspecified application

Species

Unspecified reactive species

Yujie Zhong,Ruyi Jin,Ruilin Luo,Jiayu Liu,Luting Ren,Yinghan Zhang,Zhongguo Shan,Xiaoli Peng

Journal of cellular physiology 238:2135-2146 PubMed37565586

2023

Matrix stiffness regulates neovascular homeostasis through autophagy in nude mice.

Applications

Unspecified application

Species

Unspecified reactive species

Bingqing Wang,Yuqing Yang,Yichen Wang,Yanxin Yang,Yi Li,Chenxi Hu,Changyue Xue

International journal of molecular sciences 21: PubMed32466385

2020

Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Claudia Espinosa-Garcia,Fahim Atif,Seema Yousuf,Iqbal Sayeed,Gretchen N Neigh,Donald G Stein

Biochemical and biophysical research communication 514:1185-1191 PubMed31103260

2019

The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Weizhe Lu,Jun-Dal Kim,Saori Tabara,Chulwon Kwon,Hayase Mizukami,Keiji Kimura,Akiyoshi Fukamizu

Nature communications 10:1973 PubMed31036822

2019

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Qiyao Chai,Xudong Wang,Lihua Qiang,Yong Zhang,Pupu Ge,Zhe Lu,Yanzhao Zhong,Bingxi Li,Jing Wang,Lingqiang Zhang,Dawang Zhou,Wei Li,Wenzhu Dong,Yu Pang,George Fu Gao,Cui Hua Liu

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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3-Methyladenine, selective PI3K inhibitor