3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor (ab145628)
Key features and details
- Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor.
- CAS Number: 120964-45-6
- Purity: > 98%
- Soluble in water to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor -
製品の詳細
Lysine methyltransferase EZH2 inhibitor. Highly potent, competitive s-adenosylhomocysteine hydrolase inhibitor. -
別名
- DZNep hydrochloride
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精製度
> 98% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 2444 3-Deazaneplanocin A hydrochloride. 2444-250 is the same size as the 250 µg size of ab145628.
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CAS 番号
120964-45-6 -
構造式
製品の特性
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体系名
5-(4-Aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol hydrochloride -
分子量
298.73 -
分子式
C12H14N4O3.HCl -
PubChem 登録番号
358176 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 10 mM and in DMSO to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl -
由来
Synthetic
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研究分野
画像
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Chemical Structure - 3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor (ab145628)2D chemical structure image of ab145628, 3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab145628 は 2 報の論文で使用されています。
- Duncan EJ et al. Genome Architecture Facilitates Phenotypic Plasticity in the Honeybee (Apis mellifera). Mol Biol Evol 37:1964-1978 (2020). PubMed: 32134461
- Harachi M et al. Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM. Mol Cancer Res 18:1142-1152 (2020). PubMed: 32366675