3-BrB-PP1, Akt inhibitor (ab143756)
Key features and details
- Small molecule Akt inhibitor.
- CAS Number: 956025-99-3
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
3-BrB-PP1, Akt inhibitor -
製品の詳細
Small molecule Akt inhibitor. -
別名
- 3-[(3-Bromophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- 4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine
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CAS 番号
956025-99-3 -
構造式
製品の特性
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体系名
4-Amino-1-tert-butyl-3-(3-bromobenzyl)pyrazolo[3,4-d]pyrimidine -
分子量
360.25 -
分子式
C16H18BrN5 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
画像
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Chemical Structure - 3-BrB-PP1, Akt inhibitor (ab143756)2D chemical structure image of ab143756, 3-BrB-PP1, Akt inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab143756 は 9 報の論文で使用されています。
- Bhattacharjee R et al. Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast. Elife 12:N/A (2023). PubMed: 36749320
- Prieto-Ruiz F et al. Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism. Elife 12:N/A (2023). PubMed: 36825780
- Budden AM et al. Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1. Elife 12:N/A (2023). PubMed: 37615341
- Igarashi MG et al. Polarity kinases that phosphorylate F-BAR protein Cdc15 have unique localization patterns during cytokinesis and contributions to preventing tip septation in Schizosaccharomyces pombe. MicroPubl Biol 2023:N/A (2023). PubMed: 37746062
- Zach R & Carr AM Increased expression of Pold does not alter the canonical replication program in vivo. Wellcome Open Res 6:44 (2021). PubMed: 33796794
- Gómez-Gil E et al. Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels. Elife 9:N/A (2020). PubMed: 32915139
- Patterson JO et al. Noisy Cell-Size-Correlated Expression of Cyclin B Drives Probabilistic Cell-Size Homeostasis in Fission Yeast. Curr Biol 29:1379-1386.e4 (2019). PubMed: 30955932
- Hörmann A et al. RIOK1 kinase activity is required for cell survival irrespective of MTAP status. Oncotarget 9:28625-28637 (2018). PubMed: 29983885
- Rothe C et al. A checkpoint-independent mechanism delays entry into mitosis after UV irradiation. J Cell Sci 130:4028-4037 (2017). PubMed: 29046339