Fructose-1,6-Bisphosphate Assay Kit (Fluorometic)

補足情報

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Biological function summary

Fructose 16 bisphosphate serves as a pivotal intermediate in the glycolytic pathway. It originates from the phosphorylation of fructose 6-phosphate by the enzyme phosphofructokinase-1. The compound's high energy content facilitates its role in the metabolic cycle which directly influences the ATP yield in cells. Fructose 1 6 bisphosphate also acts as a signaling molecule connecting to various metabolic processes and is part of the pyruvate kinase enzyme complex. This relationship highlights its significance in sustaining cellular energy requirements.

Pathways

Fructose 16 bisphosphate plays a fundamental role in glycolysis and gluconeogenesis. In glycolysis its formation represents a commitment step catalyzed by phosphofructokinase-1 distinctly connecting it to enzymes such as aldolase which splits it into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. In gluconeogenesis fructose 16 bisphosphate is converted back into fructose 6-phosphate a process catalyzed by fructose 16-bisphosphatase. This conversion highlights its dual function in energy generation and glucose synthesis linking fructose 1 6 BP to many metabolic cycle proteins and processes.