Key features and details
- Rabbit polyclonal to pro Caspase-12
- Suitable for: IHC-P, ICC/IF, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
保存方法Shipped at 4°C. Store at +4°C. Do Not Freeze.
バッファーPreservative: 0.02% Sodium azide
Concentration information loading...
Our Abpromise guarantee covers the use of ab8117 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 2 µg/ml.|
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 55 kDa.|
関連性Caspase 12 is activated by ER stress, including disruption of ER calcium homeostasis and mediates ER stress-induced apoptosis. Caspase 12 is co-localized to the ER with several proteins that are involved in Alzheimers disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase 12 mediates cytotoxicity induced by amyloid-beta. It is ubiquitously expressed in mouse tissue.
- CASP12 antibody
- CASP12P1 antibody
All lanes : Anti-pro Caspase-12 antibody (ab8117) at 1 µg/ml
Lane 1 : Murine brain tissue lysate with absence of blocking peptide
Lane 2 : Murine brain tissue lysate with presence of blocking peptide
ab8117 staining Caspase-12 in mouse liver tissue by IHC
Immunofluorescence of Caspase-12 in Mouse Liver cells using ab8117 at 10 ug/ml.
ab8117 は 3 報の論文で使用されています。
- Liu H et al. YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway. Oncol Lett 18:6752-6758 (2019). PubMed: 31807184
- Shen B et al. Mechanism of HN-3 cell apoptosis induced by carboplatin: Combination of mitochondrial pathway associated with Ca2+ and the nucleus pathways. Mol Med Rep 18:4978-4986 (2018). PubMed: 30272304
- Fatma N et al. Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol 301:C954-67 (2011). PubMed: 21677259