Anti-Polymeric immunoglobulin receptor/PIGR 抗体 (ab96196)
Key features and details
- Rabbit polyclonal to Polymeric immunoglobulin receptor/PIGR
- Suitable for: WB, IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Polymeric immunoglobulin receptor/PIGR antibody
Polymeric immunoglobulin receptor/PIGR 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Polymeric immunoglobulin receptor/PIGR -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-P, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment corresponding to Human Polymeric immunoglobulin receptor/PIGR aa 180-429.
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ポジティブ・コントロール
- 293T, A431, H1299, HeLa, HepG2, Molt4 and Raji cells; Cal27 xenograft tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96196の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (3) |
1/500 - 1/300. Predicted molecular weight: 83 kDa.
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IHC-P |
1/100 - 1/500.
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ICC/IF | (2) |
1/100 - 1/200.
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特記事項 |
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WB
1/500 - 1/300. Predicted molecular weight: 83 kDa. |
IHC-P
1/100 - 1/500. |
ICC/IF
1/100 - 1/200. |
ターゲット情報
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機能
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. -
配列類似性
Contains 5 Ig-like V-type (immunoglobulin-like) domains. -
翻訳後修飾
N-glycosylation is not necessary for Ig binding. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 5284 Human
- Omim: 173880 Human
- SwissProt: P01833 Human
- Unigene: 497589 Human
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別名
- Hepatocellular carcinoma associated protein TB6 antibody
- Hepatocellular carcinoma-associated protein TB6 antibody
- MGC125361 antibody
see all
画像
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Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg
Predicted band size: 83 kDa -
ab96196 at 1/200 dilution staining Polymeric immunoglobulin receptor/PIGR in methanol fixed HepG2 cells. Lower image is co-stained with Hoechst 33342.
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ab96196 at 1/500 dilution staining Polymeric immunoglobulin receptor/PIGR in paraffin-embedded Cal27 xenograft tissue.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab96196 は 8 報の論文で使用されています。
- Deluco B & Wilson HL Assessment of intestinal macromolecular absorption in young piglets to pave the way to oral vaccination: preliminary results. Vet Res Commun 46:79-91 (2022). PubMed: 34559380
- Biswas S et al. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature N/A:N/A (2021). PubMed: 33536615
- Ohkuma R et al. High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer. Oncol Rep 44:252-262 (2020). PubMed: 32627041
- Deleon-Pennell KY et al. Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure. ACS Omega 4:1272-1280 (2019). PubMed: 30729226
- Zhou M et al. Expression of polymeric immunoglobulin receptor and its biological function in endometrial adenocarcinoma. J Cancer Res Ther 15:420-425 (2019). PubMed: 30964121
- Huang L et al. A study on the mechanism of agonists in regulating transcriptional level of pIgR in salivary gland epithelial cells. Exp Ther Med 16:4367-4372 (2018). PubMed: 30542385
- Minghui Z et al. Analysis of Differentially Expressed Proteins Involved in Autoimmune Cirrhosis and Normal Serum by iTRAQ Proteomics. Proteomics Clin Appl N/A:e1700153 (2018). PubMed: 29999587
- Casey CA et al. Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells. Biomolecules 8:N/A (2018). PubMed: 30453527