Anti-Poliovirus Receptor/PVR 抗体 (ab103630)
Key features and details
- Rabbit polyclonal to Poliovirus Receptor/PVR
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Poliovirus Receptor/PVR antibody
Poliovirus Receptor/PVR 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Poliovirus Receptor/PVR -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein within Human Poliovirus Receptor/PVR aa 1-450. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_006496.2 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab103630の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 45 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 45 kDa. |
ターゲット情報
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機能
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. -
配列類似性
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 5817 Human
- Entrez Gene: 52118 Mouse
- Omim: 173850 Human
- SwissProt: P15151 Human
- SwissProt: Q91WP1 Mouse
- Unigene: 171844 Human
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別名
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
see all
画像
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Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution + Mouse stomach tissue lysate at 50 µg
Predicted band size: 45 kDa -
All lanes : Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution
Lane 1 : Poliovirus Receptor/PVR transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 45 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (4)
ab103630 は 4 報の論文で使用されています。
- Zheng Q et al. CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer. Cancer Sci 111:383-394 (2020). PubMed: 31830330
- Duan X et al. Expression of TIGIT/CD155 and correlations with clinical pathological features in human hepatocellular carcinoma. Mol Med Rep 20:3773-3781 (2019). PubMed: 31485637
- Zheng Q et al. CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. J Cell Mol Med 22:131-140 (2018). PubMed: 28816021
- Gao J et al. CD155 downregulation synergizes with adriamycin to induce breast cancer cell apoptosis. Apoptosis 23:512-520 (2018). PubMed: 30039180