PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors (ab120559)
Key features and details
- Positive allosteric modulator for the α7 nicotinic acetylcholine receptor
- CAS Number: 501925-31-1
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors -
製品の詳細
Positive allosteric modulator for the α7 nicotinic acetylcholine receptor -
生理活性の詳細
Competitive, type II positive allosteric modulator for α7nAChR (EC50 = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
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CAS 番号
501925-31-1 -
構造式
製品の特性
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体系名
N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)urea -
分子量
311.72 -
分子式
C13H14ClN3O4 -
PubChem 登録番号
311434 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl -
由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120559 は 1 報の論文で使用されています。
- Ibrahim AbdEl Fattah L et al. The Effect of Thymoquinone, a7 Receptor Agonist and a7 Receptor Allosteric Modulator on the Cerebral Cortex in Experimentally Induced Alzheimer's Disease in Relation to MSCs Activation. Int J Stem Cells 9:230-238 (2016). Functional Studies . PubMed: 27572711